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UniProt functional annotation for Q5ZX22 | ||
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| UniProt code: Q5ZX22. |
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| Organism: | |
Legionella pneumophila subsp. pneumophila (strain Philadelphia 1 / ATCC 33152 / DSM 7513). |
| Taxonomy: | |
Bacteria; Proteobacteria; Gammaproteobacteria; Legionellales; Legionellaceae; Legionella. |
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| Function: | |
Catalyzes the phosphorylation of pantothenate (Pan), the first step in CoA biosynthesis. {ECO:0000255|HAMAP-Rule:MF_01274}. |
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| Catalytic activity: | |
Reaction=(R)-pantothenate + ATP = (R)-4'-phosphopantothenate + ADP + H(+); Xref=Rhea:RHEA:16373, ChEBI:CHEBI:10986, ChEBI:CHEBI:15378, ChEBI:CHEBI:29032, ChEBI:CHEBI:30616, ChEBI:CHEBI:456216; EC=2.7.1.33; Evidence={ECO:0000255|HAMAP-Rule:MF_01274}; |
| Cofactor: | |
Name=NH4(+); Xref=ChEBI:CHEBI:28938; Evidence={ECO:0000255|HAMAP-Rule:MF_01274}; Name=K(+); Xref=ChEBI:CHEBI:29103; Evidence={ECO:0000255|HAMAP-Rule:MF_01274}; Note=A monovalent cation. Ammonium or potassium. {ECO:0000255|HAMAP- Rule:MF_01274}; |
| Pathway: | |
Cofactor biosynthesis; coenzyme A biosynthesis; CoA from (R)- pantothenate: step 1/5. {ECO:0000255|HAMAP-Rule:MF_01274}. |
| Subunit: | |
Homodimer. {ECO:0000255|HAMAP-Rule:MF_01274}. |
| Subcellular location: | |
Cytoplasm {ECO:0000255|HAMAP-Rule:MF_01274}. |
| Similarity: | |
Belongs to the type III pantothenate kinase family. {ECO:0000255|HAMAP-Rule:MF_01274}. |
Annotations taken from UniProtKB at the EBI.