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UniProt functional annotation for P00883 | ||
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| UniProt code: P00883. |
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| Organism: | |
Oryctolagus cuniculus (Rabbit). |
| Taxonomy: | |
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Lagomorpha; Leporidae; Oryctolagus. |
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| Function: | |
Plays a key role in glycolysis and gluconeogenesis. In addition, may also function as scaffolding protein. {ECO:0000269|PubMed:17329259}. |
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| Catalytic activity: | |
Reaction=beta-D-fructose 1,6-bisphosphate = D-glyceraldehyde 3- phosphate + dihydroxyacetone phosphate; Xref=Rhea:RHEA:14729, ChEBI:CHEBI:32966, ChEBI:CHEBI:57642, ChEBI:CHEBI:59776; EC=4.1.2.13; Evidence={ECO:0000269|PubMed:20129922}; |
| Pathway: | |
Carbohydrate degradation; glycolysis; D-glyceraldehyde 3- phosphate and glycerone phosphate from D-glucose: step 4/4. |
| Subunit: | |
Homotetramer. Interacts with SNX9 and WAS. Interacts with FBP2; the interaction blocks FBP2 inhibition by physiological concentrations of AMP and reduces inhibition by Ca(2+). {ECO:0000269|PubMed:10504235, ECO:0000269|PubMed:15757649, ECO:0000269|PubMed:17329259, ECO:0000269|PubMed:18214967, ECO:0000269|PubMed:18453690, ECO:0000269|PubMed:20129922}. |
| Subcellular location: | |
Cytoplasm, myofibril, sarcomere, I band {ECO:0000269|PubMed:15757649}. Cytoplasm, myofibril, sarcomere, M line {ECO:0000269|PubMed:15757649}. Note=In skeletal muscle, accumulates around the M line and within the I band, colocalizing with FBP2 on both sides of the Z line in the absence of Ca(2+). |
| Ptm: | |
Asn-361 in form alpha is deaminated to Asp in form beta. |
| Miscellaneous: | |
In vertebrates, three forms of this ubiquitous glycolytic enzyme are found, aldolase A in muscle, aldolase B in liver and aldolase C in brain. |
| Miscellaneous: | |
Alkylation of Arg-43 inactivates the enzyme. |
| Similarity: | |
Belongs to the class I fructose-bisphosphate aldolase family. {ECO:0000305}. |
Annotations taken from UniProtKB at the EBI.