PDBsum entry 3df2 Go to PDB code:  Tunnel analysis for: 3df2 calculated with MOLE 2.0 PDB id 3df2 Tunnels calculated on whole structure Tunnels calculated excluding ligands View options MOLEonline 2.0 manipulation and visualization with HETATM: without HETATM:   11 tunnels, coloured by tunnel radius 48 tunnels, coloured by tunnel radius 48 tunnels, coloured as in list below Tunnels are interior spaces connected with the protein surrounding. Only channels longer than 15 Å are shown. Tunnels Free R Length HPathy HPhob Polar Rel Mut Residue..type Ligands Radius 1 1.66 1.66 93.8 -0.57 -0.58 7.4 87 5 0 2 3 0 0 0  A 460 B C 461 B A 470 B A 471 B A 508 B A 572 B U 573 B A 574 B U 576 B G 577 B G 578 B U 1255 B G 1256 B U 1258 B G 1259 B A 1321 B A 2015 B U 2016 B U 2017 B G 2018 B A 2019 B G 2029 B A 2031 B G 2032 B A 2033 B G 2035 B C 2055 B G 2057 B A 2058 B A 2453 B C 2499 B U 2500 B MG 3014 B MG 3206 B MG 3295 B 2 1.50 1.50 97.4 -0.56 -0.57 7.6 87 5 0 2 3 0 0 0  A 460 B C 461 B A 470 B A 471 B A 508 B A 572 B U 573 B A 574 B U 576 B G 577 B G 578 B U 1255 B G 1256 B U 1258 B G 1259 B A 1321 B A 2015 B U 2016 B U 2017 B G 2018 B A 2019 B G 2029 B A 2031 B G 2032 B A 2033 B G 2035 B C 2055 B G 2057 B A 2058 B A 2453 B G 2454 B C 2499 B MG 3206 B MG 3295 B 3 1.56 1.61 107.4 -1.11 -0.74 9.3 76 4 1 2 1 1 1 0  G 15 B C 16 B G 17 B G 524 B U 525 B G 533 B U 534 B G 535 B G 551 B U 552 B G 553 B U 554 B G 555 B A 556 B A 572 B U 573 B A 574 B C 1221 B A 2020 B C 2021 B U 2022 B G 2029 B A 2031 B G 2032 B A 2033 B U 2034 B G 2035 B C 2045 B A 2054 B C 2055 B A 2453 B C 2499 B U 2500 B U 2615 B C 2616 B MG 3206 B 4 1.41 1.41 106.4 -0.60 -0.73 5.3 78 1 2 0 0 1 0 0  C 88 A U 89 A A 572 B U 573 B A 574 B U 958 B A 959 B G 1026 B A 1129 B U 1130 B A 1134 B G 2024 B C 2025 B G 2027 B G 2029 B A 2031 B G 2032 B A 2033 B U 2034 B G 2035 B G 2053 B A 2054 B C 2055 B A 2453 B G 2455 B C 2456 B U 2457 B G 2458 B A 2459 B U 2460 B A 2461 B G 2485 B C 2486 B G 2487 B G 2488 B U 2489 B G 2490 B C 2499 B U 2500 B MG 3206 B MG 3412 B MG 3418 B 5 1.51 1.51 108.4 -0.42 -0.80 3.5 95 1 0 0 0 0 0 0  G 84 A G 85 A G 86 A U 87 A C 88 A A 572 B U 573 B A 574 B C 961 B A 979 B A 1001 B G 1002 B G 1003 B G 1025 B G 1026 B A 1129 B U 1130 B A 1134 B C 1145 B C 1146 B A 1147 B U 1148 B G 2024 B C 2025 B G 2027 B U 2028 B G 2029 B A 2031 B G 2032 B A 2033 B U 2034 B G 2035 B G 2053 B A 2054 B C 2055 B A 2453 B G 2455 B C 2456 B U 2457 B G 2490 B C 2499 B U 2500 B MG 3206 B MG 3412 B MG 3418 B 6 1.51 1.52 111.1 -1.08 -0.74 8.8 76 4 1 2 1 1 1 0  G 15 B C 16 B G 17 B G 524 B U 525 B G 533 B U 534 B G 535 B G 551 B U 552 B G 553 B U 554 B G 555 B A 556 B A 572 B U 573 B A 574 B C 1221 B A 2020 B C 2021 B U 2022 B G 2029 B A 2031 B G 2032 B A 2033 B U 2034 B G 2035 B C 2045 B A 2054 B C 2055 B A 2453 B G 2454 B C 2499 B U 2615 B C 2616 B MG 3206 B 7 1.64 1.64 111.8 -0.73 -0.79 5.9 83 2 0 1 0 0 0 0  A 572 B U 573 B A 574 B U 576 B G 577 B G 578 B A 752 B U 1255 B G 1256 B A 2015 B U 2016 B U 2017 B G 2018 B A 2019 B G 2029 B A 2031 B G 2032 B A 2033 B G 2035 B C 2055 B G 2057 B A 2058 B A 2059 B G 2061 B A 2062 B A 2451 B A 2453 B C 2499 B U 2500 B G 2505 B U 2506 B C 2573 B G 2583 B U 2584 B U 2585 B A 2602 B U 2609 B C 2610 B C 2611 B MG 3206 B MG 3295 B 8 1.31 1.31 110.0 -0.60 -0.73 5.4 78 1 2 0 0 1 0 0  C 88 A U 89 A A 572 B U 573 B A 574 B U 958 B A 959 B G 1026 B A 1129 B U 1130 B A 1134 B G 2024 B C 2025 B G 2027 B G 2029 B A 2031 B G 2032 B A 2033 B U 2034 B G 2035 B G 2053 B A 2054 B C 2055 B A 2453 B G 2454 B G 2455 B C 2456 B U 2457 B G 2458 B A 2459 B U 2460 B A 2461 B G 2485 B C 2486 B G 2487 B G 2488 B U 2489 B G 2490 B C 2499 B MG 3206 B MG 3412 B MG 3418 B 9 1.38 1.38 112.0 -0.72 -0.77 6.3 86 0 3 1 0 1 0 0  A 572 B U 573 B A 574 B A 1020 B A 1021 B G 1022 B U 1023 B G 1026 B A 1127 B G 1128 B A 1129 B U 1130 B A 1133 B A 1134 B G 2024 B C 2025 B G 2027 B G 2029 B A 2031 B G 2032 B A 2033 B U 2034 B G 2035 B G 2053 B A 2054 B C 2055 B A 2453 B G 2455 B C 2456 B G 2490 B C 2499 B U 2500 B A 2541 B A 2741 B A 2757 B A 2758 B MG 3206 B MG 3412 B MG 3418 B 10 1.34 1.34 112.1 -0.42 -0.80 3.5 95 1 0 0 0 0 0 0  G 84 A G 85 A G 86 A U 87 A C 88 A A 572 B U 573 B A 574 B C 961 B A 979 B A 1001 B G 1002 B G 1003 B G 1025 B G 1026 B A 1129 B U 1130 B A 1134 B C 1145 B C 1146 B A 1147 B U 1148 B G 2024 B C 2025 B G 2027 B U 2028 B G 2029 B A 2031 B G 2032 B A 2033 B U 2034 B G 2035 B G 2053 B A 2054 B C 2055 B A 2453 B G 2454 B G 2455 B C 2456 B U 2457 B G 2490 B C 2499 B MG 3206 B MG 3412 B MG 3418 B 11 1.53 1.53 115.4 -0.72 -0.79 5.8 83 2 0 1 0 0 0 0  A 572 B U 573 B A 574 B U 576 B G 577 B G 578 B A 752 B U 1255 B G 1256 B A 2015 B U 2016 B U 2017 B G 2018 B A 2019 B G 2029 B A 2031 B G 2032 B A 2033 B G 2035 B C 2055 B G 2057 B A 2058 B A 2059 B G 2061 B A 2062 B A 2451 B A 2453 B G 2454 B C 2499 B G 2505 B U 2506 B C 2573 B G 2583 B U 2584 B U 2585 B A 2602 B U 2609 B C 2610 B C 2611 B MG 3206 B MG 3295 B 12 1.58 1.59 119.1 -1.20 -0.76 9.7 78 5 1 2 0 0 1 0  A 529 B A 572 B U 573 B A 574 B A 2020 B C 2021 B U 2022 B C 2023 B G 2029 B A 2031 B G 2032 B A 2033 B U 2034 B G 2035 B A 2042 B C 2043 B C 2044 B C 2045 B A 2054 B C 2055 B A 2453 B C 2499 B U 2500 B U 2615 B C 2616 B U 2617 B G 2618 B C 2619 B U 2622 B G 2623 B G 2624 B A 2634 B A 2635 B C 2636 B U 2637 B G 2638 B G 2770 B C 2771 B C 2772 B C 2773 B C 2774 B G 2775 B A 2776 B G 2777 B A 2778 B C 2827 B MG 3206 B 13 1.52 1.52 115.6 -0.73 -0.76 6.2 86 0 3 1 0 1 0 0  A 572 B U 573 B A 574 B A 1020 B A 1021 B G 1022 B U 1023 B G 1026 B A 1127 B G 1128 B A 1129 B U 1130 B A 1133 B A 1134 B G 2024 B C 2025 B G 2027 B G 2029 B A 2031 B G 2032 B A 2033 B U 2034 B G 2035 B G 2053 B A 2054 B C 2055 B A 2453 B G 2454 B G 2455 B C 2456 B G 2490 B C 2499 B A 2541 B A 2741 B A 2757 B A 2758 B MG 3206 B MG 3412 B MG 3418 B 14 1.57 1.62 122.7 -1.19 -0.76 9.5 78 5 1 2 0 0 1 0  A 529 B A 572 B U 573 B A 574 B A 2020 B C 2021 B U 2022 B C 2023 B G 2029 B A 2031 B G 2032 B A 2033 B U 2034 B G 2035 B A 2042 B C 2043 B C 2044 B C 2045 B A 2054 B C 2055 B A 2453 B G 2454 B C 2499 B U 2615 B C 2616 B U 2617 B G 2618 B C 2619 B U 2622 B G 2623 B G 2624 B A 2634 B A 2635 B C 2636 B U 2637 B G 2638 B G 2770 B C 2771 B C 2772 B C 2773 B C 2774 B G 2775 B A 2776 B G 2777 B A 2778 B C 2827 B MG 3206 B 15 1.56 1.56 127.6 -0.45 -0.79 3.9 83 2 0 0 0 0 0 0  U 87 A C 88 A A 572 B U 573 B A 574 B C 961 B A 979 B G 1024 B G 1025 B G 1026 B A 1027 B A 1028 B A 1029 B C 1030 B G 1031 B A 1032 B G 1116 B C 1117 B C 1118 B U 1119 B G 1120 B C 1121 B G 1122 B A 1129 B U 1130 B A 1134 B G 2024 B C 2025 B G 2027 B U 2028 B G 2029 B A 2031 B G 2032 B A 2033 B U 2034 B G 2035 B G 2053 B A 2054 B C 2055 B A 2453 B G 2455 B C 2456 B U 2457 B G 2490 B C 2499 B U 2500 B MG 3206 B MG 3412 B MG 3418 B 16 1.63 1.63 135.6 -0.62 -0.78 5.8 86 2 0 1 0 0 0 0  U 80 A G 81 A U 82 A G 83 A G 84 A G 85 A G 86 A U 87 A C 88 A C 92 A C 93 A U 95 A G 96 A C 97 A G 98 A A 572 B U 573 B A 574 B G 950 B C 961 B A 979 B C 985 B A 1129 B U 1130 B A 1134 B G 2024 B C 2025 B G 2027 B U 2028 B G 2029 B A 2031 B G 2032 B A 2033 B U 2034 B G 2035 B G 2053 B A 2054 B C 2055 B A 2453 B G 2455 B C 2456 B U 2457 B G 2490 B C 2499 B U 2500 B MG 3206 B MG 3412 B MG 3418 B 17 1.31 1.31 139.3 -0.66 -0.78 6.2 86 2 0 1 0 0 0 0  U 80 A G 81 A U 82 A G 83 A G 84 A G 85 A G 86 A U 87 A C 88 A C 92 A C 93 A U 95 A G 96 A C 97 A G 98 A A 572 B U 573 B A 574 B G 950 B C 961 B A 979 B C 985 B A 1129 B U 1130 B A 1134 B G 2024 B C 2025 B G 2027 B U 2028 B G 2029 B A 2031 B G 2032 B A 2033 B U 2034 B G 2035 B G 2053 B A 2054 B C 2055 B A 2453 B G 2454 B G 2455 B C 2456 B U 2457 B G 2490 B C 2499 B MG 3206 B MG 3412 B MG 3418 B 18 1.40 1.40 142.1 -0.43 -0.74 4.5 88 2 0 1 2 0 0 0  G 81 A U 82 A G 83 A G 84 A G 85 A G 86 A U 87 A C 88 A G 96 A C 97 A A 572 B U 573 B A 574 B C 851 B U 852 B C 853 B U 919 B A 920 B G 949 B G 950 B C 961 B C 968 B A 979 B C 985 B C 986 B A 1129 B U 1130 B A 1134 B G 2024 B C 2025 B G 2027 B U 2028 B G 2029 B A 2031 B G 2032 B A 2033 B U 2034 B G 2035 B G 2053 B A 2054 B C 2055 B A 2453 B G 2455 B C 2456 B U 2457 B G 2490 B C 2499 B U 2500 B MG 3206 B MG 3412 B MG 3418 B 19 1.55 1.55 146.9 -0.41 -0.80 3.3 107 0 0 0 0 0 0 0  C 88 A U 89 A A 572 B U 573 B A 574 B A 821 B G 822 B G 836 B C 837 B C 922 B G 923 B C 935 B A 936 B A 947 B C 948 B G 949 B G 950 B C 951 B G 953 B U 958 B A 960 B C 961 B U 963 B C 964 B C 965 B U 967 B C 968 B A 979 B A 980 B A 1129 B U 1130 B A 1134 B G 2024 B C 2025 B G 2027 B U 2028 B G 2029 B A 2031 B G 2032 B A 2033 B U 2034 B G 2035 B G 2053 B A 2054 B C 2055 B G 2269 B A 2270 B G 2355 B U 2356 B A 2453 B G 2454 B G 2455 B C 2456 B U 2457 B G 2490 B C 2499 B MG 3096 B MG 3206 B MG 3412 B MG 3418 B 20 1.31 1.31 143.3 -0.41 -0.80 3.3 107 0 0 0 0 0 0 0  C 88 A U 89 A A 572 B U 573 B A 574 B A 821 B G 822 B G 836 B C 837 B C 922 B G 923 B C 935 B A 936 B A 947 B C 948 B G 949 B G 950 B C 951 B G 953 B U 958 B A 960 B C 961 B U 963 B C 964 B C 965 B U 967 B C 968 B A 979 B A 1129 B U 1130 B A 1134 B G 2024 B C 2025 B G 2027 B U 2028 B G 2029 B A 2031 B G 2032 B A 2033 B U 2034 B G 2035 B G 2053 B A 2054 B C 2055 B G 2269 B A 2270 B G 2355 B U 2356 B A 2453 B G 2455 B C 2456 B U 2457 B G 2490 B C 2499 B U 2500 B MG 3096 B MG 3206 B MG 3412 B MG 3418 B 21 1.53 1.53 145.7 -0.42 -0.73 4.6 88 2 0 1 2 0 0 0  G 81 A U 82 A G 83 A G 84 A G 85 A G 86 A U 87 A C 88 A G 96 A C 97 A A 572 B U 573 B A 574 B C 851 B U 852 B C 853 B U 919 B A 920 B G 949 B G 950 B C 961 B C 968 B A 979 B C 985 B C 986 B A 1129 B U 1130 B A 1134 B G 2024 B C 2025 B G 2027 B U 2028 B G 2029 B A 2031 B G 2032 B A 2033 B U 2034 B G 2035 B G 2053 B A 2054 B C 2055 B A 2453 B G 2454 B G 2455 B C 2456 B U 2457 B G 2490 B C 2499 B MG 3206 B MG 3412 B MG 3418 B 22 1.67 1.67 152.7 -0.65 -0.79 5.3 83 2 0 1 0 0 0 0  A 572 B U 573 B A 574 B U 576 B G 577 B G 578 B U 741 B A 742 B A 752 B U 1255 B G 1256 B A 1672 B G 1673 B C 1675 B A 1690 B U 1765 B G 1766 B G 1767 B C 1768 B U 1769 B A 1977 B A 1978 B U 1979 B G 1980 B A 1981 B U 1982 B G 1983 B C 1985 B C 1986 B A 2015 B U 2016 B U 2017 B G 2018 B A 2019 B G 2029 B A 2031 B G 2032 B A 2033 B G 2035 B C 2055 B G 2057 B A 2058 B A 2059 B A 2062 B A 2453 B C 2499 B U 2500 B G 2582 B U 2584 B U 2586 B G 2608 B U 2609 B C 2610 B C 2611 B MG 3206 B MG 3295 B 23 1.51 1.50 154.7 -1.03 -0.68 9.1 76 8 1 2 1 1 2 0  A 529 B A 572 B U 573 B A 574 B C 1996 B A 2020 B C 2021 B U 2022 B C 2023 B G 2029 B A 2031 B G 2032 B A 2033 B U 2034 B G 2035 B A 2042 B C 2043 B C 2044 B C 2045 B A 2054 B C 2055 B A 2453 B C 2499 B U 2500 B A 2513 B U 2514 B G 2545 B U 2615 B C 2616 B U 2617 B G 2618 B C 2619 B C 2620 B G 2621 B U 2622 B G 2641 B G 2642 B G 2643 B G 2644 B U 2672 B G 2673 B G 2674 B C 2676 B G 2677 B C 2678 B A 2726 B A 2727 B U 2728 B G 2729 B C 2730 B C 2774 B A 2778 B MG 3206 B 24 1.54 1.54 152.0 -0.78 -0.68 7.5 81 3 2 3 3 1 1 0  U 77 A A 78 A G 86 A U 87 A C 88 A C 91 A C 92 A A 101 A U 103 A A 572 B U 573 B A 574 B A 905 B U 906 B G 907 B C 961 B A 979 B G 1024 B G 1025 B G 1026 B A 1027 B A 1028 B G 1120 B C 1121 B G 1122 B A 1129 B U 1130 B A 1134 B G 2024 B C 2025 B G 2027 B U 2028 B G 2029 B A 2031 B G 2032 B A 2033 B U 2034 B G 2035 B G 2053 B A 2054 B C 2055 B A 2453 B G 2455 B C 2456 B U 2457 B G 2490 B C 2499 B U 2500 B MG 3206 B MG 3412 B MG 3418 B 25 1.56 1.56 156.3 -0.61 -0.80 4.9 83 2 0 1 0 0 0 0  A 572 B U 573 B A 574 B U 576 B G 577 B G 578 B U 741 B A 742 B A 752 B U 1255 B G 1256 B A 1672 B G 1673 B C 1675 B A 1690 B U 1765 B G 1766 B G 1767 B C 1768 B U 1769 B A 1977 B A 1978 B U 1979 B G 1980 B A 1981 B U 1982 B G 1983 B C 1985 B C 1986 B A 2015 B U 2016 B U 2017 B G 2018 B A 2019 B G 2029 B A 2031 B G 2032 B A 2033 B G 2035 B C 2055 B G 2057 B A 2058 B A 2059 B A 2062 B A 2453 B G 2454 B C 2499 B G 2582 B U 2584 B U 2586 B G 2608 B U 2609 B C 2610 B C 2611 B MG 3206 B MG 3295 B 26 1.67 1.67 156.5 -0.66 -0.78 5.6 82 3 1 1 1 0 0 0  A 572 B U 573 B A 574 B U 576 B G 577 B G 578 B U 741 B A 742 B A 752 B U 1255 B G 1256 B A 1668 B A 1669 B A 1672 B G 1673 B G 1674 B C 1675 B U 1951 B A 1981 B G 1983 B C 1985 B C 1986 B A 1987 B G 1988 B A 2015 B U 2016 B U 2017 B G 2018 B A 2019 B G 2029 B A 2031 B G 2032 B A 2033 B G 2035 B C 2055 B G 2057 B A 2058 B A 2059 B A 2062 B A 2453 B C 2499 B U 2500 B G 2582 B U 2584 B U 2586 B G 2608 B U 2609 B C 2610 B C 2611 B MG 3206 B MG 3295 B 27 1.32 1.32 155.7 -0.78 -0.68 7.5 81 3 2 3 3 1 1 0  U 77 A A 78 A G 86 A U 87 A C 88 A C 91 A C 92 A A 101 A U 103 A A 572 B U 573 B A 574 B A 905 B U 906 B G 907 B C 961 B A 979 B G 1024 B G 1025 B G 1026 B A 1027 B A 1028 B G 1120 B C 1121 B G 1122 B A 1129 B U 1130 B A 1134 B G 2024 B C 2025 B G 2027 B U 2028 B G 2029 B A 2031 B G 2032 B A 2033 B U 2034 B G 2035 B G 2053 B A 2054 B C 2055 B A 2453 B G 2454 B G 2455 B C 2456 B U 2457 B G 2490 B C 2499 B MG 3206 B MG 3412 B MG 3418 B 28 1.54 1.54 158.3 -1.02 -0.67 9.0 76 8 1 2 1 1 2 0  A 529 B A 572 B U 573 B A 574 B C 1996 B A 2020 B C 2021 B U 2022 B C 2023 B G 2029 B A 2031 B G 2032 B A 2033 B U 2034 B G 2035 B A 2042 B C 2043 B C 2044 B C 2045 B A 2054 B C 2055 B A 2453 B G 2454 B C 2499 B A 2513 B U 2514 B G 2545 B U 2615 B C 2616 B U 2617 B G 2618 B C 2619 B C 2620 B G 2621 B U 2622 B G 2641 B G 2642 B G 2643 B G 2644 B U 2672 B G 2673 B G 2674 B C 2676 B G 2677 B C 2678 B A 2726 B A 2727 B U 2728 B G 2729 B C 2730 B C 2774 B A 2778 B MG 3206 B 29 1.56 1.56 160.1 -0.66 -0.78 5.6 82 3 1 1 1 0 0 0  A 572 B U 573 B A 574 B U 576 B G 577 B G 578 B U 741 B A 742 B A 752 B U 1255 B G 1256 B A 1668 B A 1669 B A 1672 B G 1673 B G 1674 B C 1675 B U 1951 B A 1981 B G 1983 B C 1985 B C 1986 B A 1987 B G 1988 B A 2015 B U 2016 B U 2017 B G 2018 B A 2019 B G 2029 B A 2031 B G 2032 B A 2033 B G 2035 B C 2055 B G 2057 B A 2058 B A 2059 B A 2062 B A 2453 B G 2454 B C 2499 B G 2582 B U 2584 B U 2586 B G 2608 B U 2609 B C 2610 B C 2611 B MG 3206 B MG 3295 B 30 1.66 1.66 161.4 -0.73 -0.79 6.4 79 3 1 1 0 0 0 0  A 572 B U 573 B A 574 B U 576 B G 577 B G 578 B A 735 B A 739 B U 741 B G 745 B U 746 B A 752 B A 753 B U 754 B U 755 B A 756 B G 757 B C 758 B U 1255 B G 1256 B C 1298 B G 1299 B A 1302 B U 1636 B A 1637 B G 1661 B A 1678 B A 1679 B U 1680 B G 1681 B A 1754 B A 1755 B A 1759 B C 1761 B A 1762 B U 1782 B A 2015 B U 2016 B U 2017 B G 2018 B A 2019 B G 2029 B A 2031 B G 2032 B A 2033 B G 2035 B C 2055 B G 2057 B A 2058 B A 2059 B A 2453 B C 2499 B U 2500 B U 2609 B C 2712 B C 2716 B MG 3117 B MG 3206 B MG 3295 B MG 3394 B 31 1.68 1.68 164.5 -0.95 -0.71 9.2 84 7 0 3 1 1 0 0  A 572 B U 573 B A 574 B U 576 B G 577 B G 578 B A 676 B A 677 B C 678 B C 679 B C 680 B G 681 B G 682 B A 751 B G 775 B G 776 B G 777 B U 790 B A 794 B C 795 B C 796 B U 1255 B G 1256 B U 1258 B A 1808 B A 2015 B U 2016 B U 2017 B G 2018 B A 2019 B G 2029 B A 2031 B G 2032 B A 2033 B G 2035 B C 2055 B G 2057 B A 2058 B U 2081 B A 2082 B G 2083 B U 2231 B C 2232 B U 2233 B G 2234 B G 2235 B U 2236 B G 2237 B A 2453 B C 2499 B U 2500 B MG 3014 B MG 3206 B MG 3295 B 32 1.55 1.55 165.0 -0.72 -0.79 6.3 79 3 1 1 0 0 0 0  A 572 B U 573 B A 574 B U 576 B G 577 B G 578 B A 735 B A 739 B U 741 B G 745 B U 746 B A 752 B A 753 B U 754 B U 755 B A 756 B G 757 B C 758 B U 1255 B G 1256 B C 1298 B G 1299 B A 1302 B U 1636 B A 1637 B G 1661 B A 1678 B A 1679 B U 1680 B G 1681 B A 1754 B A 1755 B A 1759 B C 1761 B A 1762 B U 1782 B A 2015 B U 2016 B U 2017 B G 2018 B A 2019 B G 2029 B A 2031 B G 2032 B A 2033 B G 2035 B C 2055 B G 2057 B A 2058 B A 2059 B A 2453 B G 2454 B C 2499 B U 2609 B C 2712 B C 2716 B MG 3117 B MG 3206 B MG 3295 B MG 3394 B 33 1.55 1.55 168.1 -0.96 -0.70 9.4 84 7 0 3 1 1 0 0  A 572 B U 573 B A 574 B U 576 B G 577 B G 578 B A 676 B A 677 B C 678 B C 679 B C 680 B G 681 B G 682 B A 751 B G 775 B G 776 B G 777 B U 790 B A 794 B C 795 B C 796 B U 1255 B G 1256 B U 1258 B A 1808 B A 2015 B U 2016 B U 2017 B G 2018 B A 2019 B G 2029 B A 2031 B G 2032 B A 2033 B G 2035 B C 2055 B G 2057 B A 2058 B U 2081 B A 2082 B G 2083 B U 2231 B C 2232 B U 2233 B G 2234 B G 2235 B U 2236 B G 2237 B A 2453 B G 2454 B C 2499 B MG 3014 B MG 3206 B MG 3295 B 34 1.71 1.71 167.9 -0.63 -0.79 5.1 77 2 0 1 0 0 1 0  A 572 B U 573 B A 574 B U 576 B G 577 B G 578 B U 703 B G 704 B A 705 B A 722 B A 727 B G 728 B A 730 B C 731 B C 732 B U 741 B A 742 B A 752 B G 759 B U 1255 B G 1256 B A 1672 B G 1673 B C 1675 B G 1695 B G 1696 B G 1697 B G 1699 B C 1764 B U 1765 B A 1978 B U 1979 B G 1980 B A 1981 B U 1982 B G 1983 B A 2015 B U 2016 B U 2017 B G 2018 B A 2019 B G 2029 B A 2031 B G 2032 B A 2033 B G 2035 B C 2055 B G 2057 B A 2058 B A 2059 B A 2062 B A 2453 B C 2499 B U 2500 B G 2582 B U 2584 B U 2586 B G 2608 B U 2609 B C 2610 B C 2611 B MG 3206 B MG 3295 B 35 1.55 1.55 171.6 -0.59 -0.79 4.6 77 2 0 1 0 0 1 0  A 572 B U 573 B A 574 B U 576 B G 577 B G 578 B U 703 B G 704 B A 705 B A 722 B A 727 B G 728 B A 730 B C 731 B C 732 B U 741 B A 742 B A 752 B G 759 B U 1255 B G 1256 B A 1672 B G 1673 B C 1675 B G 1695 B G 1696 B G 1697 B G 1699 B C 1764 B U 1765 B A 1978 B U 1979 B G 1980 B A 1981 B U 1982 B G 1983 B A 2015 B U 2016 B U 2017 B G 2018 B A 2019 B G 2029 B A 2031 B G 2032 B A 2033 B G 2035 B C 2055 B G 2057 B A 2058 B A 2059 B A 2062 B A 2453 B G 2454 B C 2499 B G 2582 B U 2584 B U 2586 B G 2608 B U 2609 B C 2610 B C 2611 B MG 3206 B MG 3295 B 36 1.70 1.70 171.0 -0.78 -0.65 8.7 75 7 1 1 2 2 0 0  A 572 B U 573 B A 574 B U 576 B G 577 B G 578 B A 676 B A 677 B C 678 B C 679 B C 680 B G 681 B G 682 B A 751 B G 775 B G 776 B G 777 B U 790 B A 794 B C 795 B C 796 B U 1255 B G 1256 B U 1258 B C 1804 B A 1805 B C 1806 B G 1807 B A 1808 B G 1845 B G 1846 B A 1847 B A 2015 B U 2016 B U 2017 B G 2018 B A 2019 B G 2029 B A 2031 B G 2032 B A 2033 B G 2035 B C 2055 B G 2057 B A 2058 B A 2082 B G 2083 B C 2084 B U 2085 B U 2086 B G 2087 B G 2239 B A 2453 B C 2499 B U 2500 B MG 3014 B MG 3206 B MG 3295 B 37 1.71 1.71 199.8 -0.85 -0.72 8.3 78 5 0 1 1 1 0 0  A 572 B U 573 B A 574 B U 576 B G 577 B G 578 B A 676 B A 677 B C 678 B C 679 B C 680 B G 681 B G 682 B A 751 B G 775 B G 776 B G 777 B U 790 B A 794 B C 795 B C 796 B U 1255 B G 1256 B U 1258 B C 1363 B A 1801 B A 1803 B C 1804 B A 1805 B C 1806 B G 1807 B A 1808 B A 1810 B A 2015 B U 2016 B U 2017 B G 2018 B A 2019 B G 2029 B A 2031 B G 2032 B A 2033 B G 2035 B C 2055 B G 2057 B A 2058 B A 2082 B G 2083 B C 2084 B U 2197 B A 2198 B A 2199 B G 2201 B U 2202 B U 2203 B G 2216 B G 2217 B G 2218 B U 2219 B U 2220 B G 2221 B C 2222 B G 2228 B U 2229 B A 2453 B C 2499 B U 2500 B MG 3014 B MG 3206 B MG 3295 B 38 2.99 2.99 17.0 -0.40 -0.80 3.4 0 0 0 0 0 0 0 0  A 2108 B U 2109 B A 2142 B C 2143 B C 2150 B U 2151 B 39 2.98 2.98 17.1 -0.40 -0.80 3.4 0 0 0 0 0 0 0 0  G 2107 B A 2108 B U 2109 B A 2142 B C 2143 B C 2150 B U 2151 B 40 3.00 3.00 20.3 -0.40 -0.80 3.4 0 0 0 0 0 0 0 0  G 2107 B A 2108 B U 2109 B A 2142 B C 2143 B C 2150 B U 2151 B U 2182 B A 2183 B 41 3.72 3.72 22.5 -0.40 -0.80 3.4 0 0 0 0 0 0 0 0  U 2106 B G 2107 B A 2108 B U 2109 B G 2141 B A 2142 B C 2143 B C 2145 B U 2151 B U 2181 B U 2182 B A 2183 B A 2184 B 42 3.47 3.47 22.7 -0.40 -0.80 3.4 0 0 0 0 0 0 0 0  U 2106 B G 2107 B G 2141 B A 2142 B C 2143 B U 2151 B U 2182 B A 2183 B A 2184 B 43 3.69 3.69 26.1 -0.40 -0.80 3.4 0 0 0 0 0 0 0 0  U 2106 B G 2107 B A 2108 B U 2109 B G 2141 B A 2142 B C 2143 B C 2145 B G 2148 B U 2149 B C 2150 B U 2151 B A 2183 B A 2184 B 44 1.45 1.46 18.6 -1.82 -0.64 22.6 72 3 1 0 0 1 0 0  A 83 B A 84 B U 100 B A 101 B 45 1.42 2.32 18.9 2.39 0.78 7.5 86 2 1 0 8 1 0 0   46 1.36 1.76 20.5 1.58 0.24 4.7 86 1 0 0 6 1 0 0   47 1.43 1.79 15.1 2.83 0.72 2.5 84 0 1 0 7 0 0 0   48 1.17 1.59 15.2 3.79 1.10 0.3 89 0 0 0 9 0 0 0   Residue-type_colouring Positive Negative Neutral Aliphatic Aromatic Pro & Gly Cysteine H,K,R D,E S,T,N,Q A,V,L,I,M F,Y,W P,G C Acknowledgement Tunnels were calculated by MOLE 2.0 program version 2.5.13.11.08 and visualized using Pymol 0.97rc.