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PDBsum entry 3de9
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Metal binding protein
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PDB id
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3de9
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References listed in PDB file
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Key reference
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Title
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Control of protein oligomerization symmetry by metal coordination: c2 and c3 symmetrical assemblies through cu(ii) and ni(ii) coordination.
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Authors
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E.N.Salgado,
R.A.Lewis,
S.Mossin,
A.L.Rheingold,
F.A.Tezcan.
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Ref.
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Inorg Chem, 2009,
48,
2726-2728.
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PubMed id
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Abstract
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We describe the metal-dependent self-assembly of symmetrical protein
homooligomers from protein building blocks that feature appropriately engineered
metal-chelating motifs on their surfaces. Crystallographic studies indicate that
the same four-helix-bundle protein construct, MBPC-1, can self-assemble into
C(2) and C(3) symmetrical assemblies dictated by Cu(II) and Ni(II) coordination,
respectively. The symmetry inherent in metal coordination can thus be directly
applied to biological self-assembly.
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