 |
PDBsum entry 3dd3
|
|
|
|
References listed in PDB file
|
 |
|
Key reference
|
|
|
Title
|
|
Rational design of an organometallic glutathione transferase inhibitor.
|
|
|
Authors
|
|
W.H.Ang,
L.J.Parker,
A.De luca,
L.Juillerat-Jeanneret,
C.J.Morton,
M.Lo bello,
M.W.Parker,
P.J.Dyson.
|
|
|
Ref.
|
|
Angew Chem Int Ed Engl, 2009,
48,
3854-3857.
|
|
|
PubMed id
|
|
|
|
|
|
Abstract
|
|
|
Double trouble: A hybrid organic-inorganic (organometallic) inhibitor was
designed to target glutathione transferases. The metal center is used to direct
protein binding, while the organic moiety acts as the active-site inhibitor (see
picture). The mechanism of inhibition was studied using a range of biophysical
and biochemical methods.
|
|
|
|
|
|
|
