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PDBsum entry 3db8
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References listed in PDB file
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Key reference
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Title
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Design and synthesis of 2-Amino-Isoxazolopyridines as polo-Like kinase inhibitors.
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Authors
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E.J.Hanan,
R.V.Fucini,
M.J.Romanowski,
R.A.Elling,
W.Lew,
H.E.Purkey,
E.C.Vanderporten,
W.Yang.
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Ref.
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Bioorg Med Chem Lett, 2008,
18,
5186-5189.
[DOI no: ]
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PubMed id
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Abstract
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A series of 2-amino-isoxazolopyridines was designed and synthesized as Polo-like
kinase (Plk) inhibitors. Key SAR and crystallographic data are discussed. More
advanced analogues inhibit Plk1 with good enzymatic activity and modest
cell-based activity. Differential selectivity among the three Plk isoforms is
observed.
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