PDBsum entry 3dac

Cell cycle

PDB id: 3dac

Contents

Protein chains

85 a.a.

12 a.a.

13 a.a.

Waters ×218

References listed in PDB file

Key reference

• Title: Structure of the human mdmx protein bound to the p53 tumor suppressor transactivation domain.
• Authors: G.M.Popowicz, A.Czarna, T.A.Holak.
• Ref.: Cell Cycle, 2008, 7, 2441-2443. [DOI no: 10.4161/cc.6365]
• PubMed id: 18677113

Abstract

The Mdmx oncoprotein has only recently emerged as a critical-independent to Mdm2-regulator of p53 activation. We have determined the crystal structure of the N-terminal domain of human Mdmx bound to a 15-residue transactivation domain peptide of human p53. The structure shows why antagonists of the Mdm2 binding to p53 are ineffective in the Mdmx-p53 interaction.