 |
PDBsum entry 3d9c
|
|
|
|
References listed in PDB file
|
 |
|
Key reference
|
|
|
Title
|
|
Seleninate in place of phosphate: irreversible inhibition of protein tyrosine phosphatases.
|
|
|
Authors
|
|
M.Abdo,
S.Liu,
B.Zhou,
C.D.Walls,
L.Wu,
S.Knapp,
Z.Y.Zhang.
|
|
|
Ref.
|
|
J Am Chem Soc, 2008,
130,
13196-13197.
|
|
|
PubMed id
|
|
|
|
|
|
Abstract
|
|
|
A homotyrosine based seleninic acid irreversibly inhibits protein tyrosine
phosphatases by forming a covalent selenosulfide linkage with the active site
cysteine sulfhydryl specifically. The details of the event are revealed by model
synthetic studies and by kinetic, mass spectrometric, and crystallographic
characterization.
|
|
|
|
|
|
|
