|
|
||
|
|
|
|
|
UniProt functional annotation for P02743 | ||
|
|
|
|
|
|
||
| UniProt code: P02743. |
|
||
| Organism: | |
Homo sapiens (Human). |
| Taxonomy: | |
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo. |
|
||
|
||
| Function: | |
Can interact with DNA and histones and may scavenge nuclear material released from damaged circulating cells. May also function as a calcium-dependent lectin. |
|
||
| Cofactor: | |
Name=Ca(2+); Xref=ChEBI:CHEBI:29108; Note=Binds 2 calcium ions per subunit.; |
| Subunit: | |
Homopentamer. Pentraxin (or pentaxin) have a discoid arrangement of 5 non-covalently bound subunits. |
| Subcellular location: | |
Secreted. |
| Tissue specificity: | |
Found in serum and urine. {ECO:0000269|PubMed:15174148}. |
| Ptm: | |
N-glycosylated with a complex biantennary oligosaccharide chain with a sialic acid at the end (disialo-SAP). Monosialo-SAP as well as asioalo-SAP are also detected (PubMed:15174148). {ECO:0000269|PubMed:15174148, ECO:0000269|PubMed:16335952, ECO:0000269|PubMed:19159218}. |
| Mass spectrometry: | |
[Serum amyloid P-component]: Mass=25462.5; Mass_error=1.1; Method=Electrospray; Evidence={ECO:0000269|PubMed:15174148, ECO:0000269|PubMed:8202534}; |
| Mass spectrometry: | |
[Serum amyloid P-component]: Mass=25463; Mass_error=3; Method=MALDI; Evidence={ECO:0000269|PubMed:15174148, ECO:0000269|PubMed:8202534}; |
| Disease: | |
Note=SAP is a precursor of amyloid component P which is found in basement membrane and associated with amyloid deposits. |
| Similarity: | |
Belongs to the pentraxin family. {ECO:0000305}. |
Annotations taken from UniProtKB at the EBI.