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UniProt functional annotation for P10761 | ||
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| UniProt code: P10761. |
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| Organism: | |
Mus musculus (Mouse). |
| Taxonomy: | |
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus. |
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| Function: | |
Component of the zona pellucida, an extracellular matrix surrounding oocytes which mediates sperm binding, induction of the acrosome reaction and prevents post-fertilization polyspermy. The zona pellucida is composed of 3 to 4 glycoproteins, ZP1, ZP2, ZP3, and ZP4. ZP3 is essential for sperm binding and zona matrix formation. |
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| Subunit: | |
Polymers of ZP2 and ZP3 organized into long filaments cross- linked by ZP1 homodimers. Interacts with ZP1 and ZP2. {ECO:0000250|UniProtKB:P20239, ECO:0000250|UniProtKB:P21754}. |
| Subcellular location: | |
[Processed zona pellucida sperm-binding protein 3]: Zona pellucida {ECO:0000269|PubMed:19052627}. |
| Subcellular location: | |
Cell membrane {ECO:0000269|PubMed:19052627}; Single-pass type I membrane protein {ECO:0000255}. |
| Tissue specificity: | |
Expressed in oocytes. |
| Developmental stage: | |
Expressed during the 2-week growth phase of oogenesis, prior to ovulation. |
| Domain: | |
The ZP domain is involved in the polymerization of the ZP proteins to form the zona pellucida. |
| Ptm: | |
Proteolytically cleaved before the transmembrane segment to yield the secreted ectodomain incorporated in the zona pellucida. |
| Ptm: | |
O-glycosylated; removal of O-linked glycans may play an important role in the post-fertilization block to polyspermy. {ECO:0000269|PubMed:12799386}. |
| Ptm: | |
Cys-320, Cys-322, Cys-323 and Cys-328 are involved in two additional disulfide bonds. |
| Similarity: | |
Belongs to the ZP domain family. ZPC subfamily. {ECO:0000305}. |
Annotations taken from UniProtKB at the EBI.