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UniProt functional annotation for Q9BUD6 | ||
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| UniProt code: Q9BUD6. |
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| Organism: | |
Homo sapiens (Human). |
| Taxonomy: | |
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo. |
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| Function: | |
Cell adhesion protein that promotes adhesion and outgrowth of hippocampal embryonic neurons. Binds directly to bacteria and their components and functions as an opsonin for macrophage phagocytosis of bacteria. Essential in the initiation of the innate immune response and represents a unique pattern-recognition molecule in the ECM for microbial pathogens (By similarity). Binds bacterial lipopolysaccharide (LPS). {ECO:0000250}. |
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| Subunit: | |
Monomer. Interacts with integrin. {ECO:0000269|PubMed:19153605}. |
| Subcellular location: | |
Secreted, extracellular space, extracellular matrix {ECO:0000250}. |
| Tissue specificity: | |
Expressed in normal lung tissue but not in lung carcinoma cell lines. {ECO:0000269|PubMed:10512675}. |
Annotations taken from UniProtKB at the EBI.