UniProt functional annotation for Q56061



	UniProt functional annotation for Q56061

UniProt code: Q56061.

Organism: Salmonella typhimurium (strain LT2 / SGSC1412 / ATCC 700720).

Taxonomy: Bacteria; Proteobacteria; Gammaproteobacteria; Enterobacterales; Enterobacteriaceae; Salmonella.

Function: Effector proteins function to alter host cell physiology and promote bacterial survival in host tissues. This protein is required for endosomal tubulation and formation of Salmonella-induced filaments (Sifs), which are filamentous structures containing lysosomal membrane glycoproteins within epithelial cells. Sif formation is concomitant with intracellular bacterial replication. {ECO:0000269|PubMed:12010459, ECO:0000269|PubMed:15905402, ECO:0000269|PubMed:18996344}.

Subunit: Interacts with host PLEKHM2. Interacts with SseJ; the interaction is indirect. {ECO:0000269|PubMed:15905402, ECO:0000269|PubMed:18996344}.

Subcellular location: Secreted. Host cytoplasm. Host cell membrane. Note=Secreted via type III secretion system 2 (SPI-2 TTSS), and delivered into the host cytoplasm. It associates with membranes and colocalizes with microtubules along the length of Sifs in infected cells.

Domain: Domains throughout the protein, and not only the N-terminus, are required for secretion and translocation. Both N- and C-terminal domains are also required for formation of tubules. {ECO:0000269|PubMed:16849798}.

Disruption phenotype: Cells lacking this gene do not produce Sifs in epithelial cells and show attenuated virulence in mice. {ECO:0000269|PubMed:8861213}.

Similarity: Belongs to the Sif family. {ECO:0000305}.

Annotations taken from UniProtKB at the EBI.


Organism:		Salmonella typhimurium (strain LT2 / SGSC1412 / ATCC 700720).
Taxonomy:		Bacteria; Proteobacteria; Gammaproteobacteria; Enterobacterales; Enterobacteriaceae; Salmonella.



Function:		Effector proteins function to alter host cell physiology and promote bacterial survival in host tissues. This protein is required for endosomal tubulation and formation of Salmonella-induced filaments (Sifs), which are filamentous structures containing lysosomal membrane glycoproteins within epithelial cells. Sif formation is concomitant with intracellular bacterial replication. {ECO:0000269\|PubMed:12010459, ECO:0000269\|PubMed:15905402, ECO:0000269\|PubMed:18996344}.


Subunit:		Interacts with host PLEKHM2. Interacts with SseJ; the interaction is indirect. {ECO:0000269\|PubMed:15905402, ECO:0000269\|PubMed:18996344}.
Subcellular location:		Secreted. Host cytoplasm. Host cell membrane. Note=Secreted via type III secretion system 2 (SPI-2 TTSS), and delivered into the host cytoplasm. It associates with membranes and colocalizes with microtubules along the length of Sifs in infected cells.
Domain:		Domains throughout the protein, and not only the N-terminus, are required for secretion and translocation. Both N- and C-terminal domains are also required for formation of tubules. {ECO:0000269\|PubMed:16849798}.
Disruption phenotype:		Cells lacking this gene do not produce Sifs in epithelial cells and show attenuated virulence in mice. {ECO:0000269\|PubMed:8861213}.
Similarity:		Belongs to the Sif family. {ECO:0000305}.