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UniProt functional annotation for P04395 | ||
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| UniProt code: P04395. |
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| Organism: | |
Escherichia coli (strain K12). |
| Taxonomy: | |
Bacteria; Proteobacteria; Gammaproteobacteria; Enterobacterales; Enterobacteriaceae; Escherichia. |
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| Function: | |
Hydrolysis of the deoxyribose N-glycosidic bond to excise 3- methyladenine, 3-methylguanine, 7-methylguanine, O2-methylthymine, and O2-methylcytosine from the damaged DNA polymer formed by alkylation lesions. |
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| Catalytic activity: | |
Reaction=Hydrolysis of alkylated DNA, releasing 3-methyladenine, 3- methylguanine, 7-methylguanine and 7-methyladenine.; EC=3.2.2.21; |
| Subunit: | |
Monomer. |
| Induction: | |
Up-regulated by methylated Ada in response to the exposure to alkylating agents. |
| Similarity: | |
Belongs to the alkylbase DNA glycosidase AlkA family. {ECO:0000305}. |
Annotations taken from UniProtKB at the EBI.