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UniProt functional annotation for Q46G05 | ||
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| UniProt code: Q46G05. |
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| Organism: | |
Methanosarcina barkeri (strain Fusaro / DSM 804). |
| Taxonomy: | |
Archaea; Euryarchaeota; Stenosarchaea group; Methanomicrobia; Methanosarcinales; Methanosarcinaceae; Methanosarcina. |
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| Function: | |
Part of a complex that catalyzes the reversible cleavage of acetyl-CoA, allowing growth on acetate as sole source of carbon and energy. The alpha-epsilon subcomponent functions as a carbon monoxide dehydrogenase (PubMed:6425262). The precise role of the epsilon subunit is unclear; it may have a stabilizing role within the alpha(2)epsilon(2) component and/or be involved in electron transfer to FAD during a potential FAD-mediated CO oxidation (PubMed:18621675). {ECO:0000255|HAMAP-Rule:MF_01134, ECO:0000269|PubMed:6425262, ECO:0000305|PubMed:18621675}. |
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| Pathway: | |
One-carbon metabolism; methanogenesis from acetate. {ECO:0000255|HAMAP-Rule:MF_01134, ECO:0000305|PubMed:6425262}. |
| Subunit: | |
Heterotetramer of two alpha and two epsilon subunits (PubMed:6425262). The ACDS complex is made up of alpha, epsilon, beta, gamma and delta subunits with a probable stoichiometry of (alpha(2)epsilon(2))(4)-beta(8)-(gamma(1)delta(1))(8) (By similarity). {ECO:0000255|HAMAP-Rule:MF_01134, ECO:0000269|PubMed:6425262, ECO:0000305|PubMed:18621675}. |
| Induction: | |
Up-regulated during growth on acetate. {ECO:0000269|PubMed:6425262}. |
| Similarity: | |
Belongs to the CdhB family. {ECO:0000255|HAMAP- Rule:MF_01134}. |
Annotations taken from UniProtKB at the EBI.