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UniProt functional annotation for P33183 | ||
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| UniProt code: P33183. |
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| Organism: | |
Sambucus nigra (European elder). |
| Taxonomy: | |
Eukaryota; Viridiplantae; Streptophyta; Embryophyta; Tracheophyta; Spermatophyta; Magnoliopsida; eudicotyledons; Gunneridae; Pentapetalae; asterids; campanulids; Dipsacales; Adoxaceae; Sambucus. |
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| Function: | |
Non-toxic type 2 RIP which strongly inhibits mammalian protein synthesis but does not affect plant nor bacterial protein synthesis. The A chain is responsible for inhibiting protein synthesis through the catalytic inactivation of 60S ribosomal subunits by removing adenine from position 4,324 of 28S rRNA. |
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| Function: | |
The B chain is a galactose-specific lectin that facilitates the binding of nigrin b to the cell membrane that precedes endocytosis. |
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| Catalytic activity: | |
Reaction=Endohydrolysis of the N-glycosidic bond at one specific adenosine on the 28S rRNA.; EC=3.2.2.22; |
| Subunit: | |
Disulfide-linked dimer of A and B chains. |
| Similarity: | |
In the N-terminal section; belongs to the ribosome- inactivating protein family. Type 2 RIP subfamily. {ECO:0000305}. |
Annotations taken from UniProtKB at the EBI.