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UniProt functional annotation for O67883 | ||
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| UniProt code: O67883. |
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| Organism: | |
Aquifex aeolicus (strain VF5). |
| Taxonomy: | |
Bacteria; Aquificae; Aquificales; Aquificaceae; Aquifex. |
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| Function: | |
Catalyzes the ATP-dependent phosphorylation of thiamine- monophosphate (TMP) to form thiamine-pyrophosphate (TPP), the active form of vitamin B1. {ECO:0000255|HAMAP-Rule:MF_02128, ECO:0000305|PubMed:18311927}. |
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| Catalytic activity: | |
Reaction=ATP + thiamine phosphate = ADP + thiamine diphosphate; Xref=Rhea:RHEA:15913, ChEBI:CHEBI:30616, ChEBI:CHEBI:37575, ChEBI:CHEBI:58937, ChEBI:CHEBI:456216; EC=2.7.4.16; Evidence={ECO:0000255|HAMAP-Rule:MF_02128}; |
| Pathway: | |
Cofactor biosynthesis; thiamine diphosphate biosynthesis; thiamine diphosphate from thiamine phosphate: step 1/1. {ECO:0000255|HAMAP-Rule:MF_02128}. |
| Subunit: | |
Homodimer. {ECO:0000269|PubMed:18311927}. |
| Miscellaneous: | |
Reaction mechanism of ThiL seems to utilize a direct, inline transfer of the gamma-phosphate of ATP to TMP rather than a phosphorylated enzyme intermediate. {ECO:0000305|PubMed:18311927}. |
| Similarity: | |
Belongs to the thiamine-monophosphate kinase family. {ECO:0000255|HAMAP-Rule:MF_02128}. |
Annotations taken from UniProtKB at the EBI.