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UniProt functional annotation for O59179 | ||
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| UniProt code: O59179. |
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| Organism: | |
Pyrococcus horikoshii (strain ATCC 700860 / DSM 12428 / JCM 9974 / NBRC 100139 / OT-3). |
| Taxonomy: | |
Archaea; Euryarchaeota; Thermococci; Thermococcales; Thermococcaceae; Pyrococcus. |
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| Function: | |
Protease that cleaves its substrates preferentially near hydrophobic or aromatic amino acid residues. Can degrade casein and the stomatin homolog PH1511 (in vitro). {ECO:0000269|PubMed:15611110, ECO:0000269|PubMed:16574150, ECO:0000269|PubMed:24121343}. |
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| Activity regulation: | |
Inhibited by divalent metal cations, including Mg(2+), Mn(2+), Ca(2+) and Zn(2+). Mildly inhibited by 0.01 % SDS and 0.1% dodecyl-beta-D-maltoside. Activity is nearly abolished by 1 % SDS. {ECO:0000269|PubMed:15611110}. |
| Biophysicochemical properties: | |
pH dependence: Optimum pH is 5-6. {ECO:0000269|PubMed:15611110}; Temperature dependence: Optimum temperature is above 90 degrees Celsius. {ECO:0000269|PubMed:15611110}; |
| Subunit: | |
Homodimer. {ECO:0000269|PubMed:15611110, ECO:0000269|PubMed:16574150, ECO:0000269|PubMed:18421152, ECO:0000269|PubMed:22475127}. |
| Subcellular location: | |
Membrane {ECO:0000305}; Multi-pass membrane protein {ECO:0000305}. |
| Similarity: | |
Belongs to the peptidase S14 family. {ECO:0000305}. |
Annotations taken from UniProtKB at the EBI.