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PDBsum entry 3bc3
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References listed in PDB file
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Key reference
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Title
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Exploring inhibitor binding at the s' Subsites of cathepsin l.
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Authors
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S.F.Chowdhury,
L.Joseph,
S.Kumar,
S.R.Tulsidas,
S.Bhat,
E.Ziomek,
R.Ménard,
J.Sivaraman,
E.O.Purisima.
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Ref.
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J Med Chem, 2008,
51,
1361-1368.
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PubMed id
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Abstract
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We report a series of noncovalent, reversible inhibitors of cathepsin L that
have been designed to explore additional binding interactions with the S'
subsites. The design was based on our previously reported crystal structure that
suggested the possibility of engineering increased interactions with the S'
subsites ( Chowdhury et al. J. Med. Chem. 2002, 45, 5321-5329 ). A
representative of these new inhibitors has been co-crystallized with mature
cathepsin L, and the structure has been solved and refined at 2.2 A. The
inhibitors described in this work extend farther into the S' subsites of
cathepsins than any inhibitors reported in the literature thus far. These
interactions appear to make use of a S3' subsite that can potentially be
exploited for enhanced specificity and/or affinity.
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