UniProt functional annotation for Q8IWJ2



	UniProt functional annotation for Q8IWJ2

UniProt code: Q8IWJ2.

Organism: Homo sapiens (Human).

Taxonomy: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo.

Function: Golgin which probably tethers transport vesicles to the trans-Golgi network (TGN) and regulates vesicular transport between the endosomes and the Golgi. As a RAB9A effector it is involved in recycling of the mannose 6-phosphate receptor from the late endosomes to the TGN. May also play a role in transport between the recycling endosomes and the Golgi. Required for maintenance of the Golgi structure, it is involved in the biogenesis of noncentrosomal, Golgi- associated microtubules through recruitment of CLASP1 and CLASP2. {ECO:0000269|PubMed:16885419, ECO:0000269|PubMed:17488291, ECO:0000269|PubMed:17543864}.

Subunit: Homodimer. Interacts (via GRIP domain) with RAB6A (preferentially in its GTP-bound form). May interact (RAB6A-dependent) with ARL1; according to PubMed:19703403, RAB6A and ARL1 are not involved in GCC2 Golgi localization as proposed by PubMed:18243103. Interacts (probably via GRIP domain) with RAB9A (preferentially in its GTP-bound form). Interacts with CLASP1 and CLASP2; recruits both proteins to membranes of the TGN. Interacts with STX16. {ECO:0000269|PubMed:16885419, ECO:0000269|PubMed:17543864, ECO:0000269|PubMed:18195106, ECO:0000269|PubMed:18243103, ECO:0000269|PubMed:19703403}.

Subcellular location: Cytoplasm. Golgi apparatus, trans-Golgi network membrane; Peripheral membrane protein.

Tissue specificity: Ubiquitous. {ECO:0000269|PubMed:11149944}.

Domain: Extended rod-like protein with coiled-coil domains.

Miscellaneous: [Isoform 2]: May be produced at very low levels due to a premature stop codon in the mRNA, leading to nonsense-mediated mRNA decay. {ECO:0000305}.

Sequence caution: Sequence=AAG34902.1; Type=Frameshift; Evidence={ECO:0000305}; Sequence=AAH37774.1; Type=Miscellaneous discrepancy; Note=Wrong choice of CDS.; Evidence={ECO:0000305}; Sequence=AAI46790.1; Type=Miscellaneous discrepancy; Note=Wrong choice of CDS.; Evidence={ECO:0000305}; Sequence=AAL99918.1; Type=Erroneous initiation; Note=Extended N-terminus.; Evidence={ECO:0000305}; Sequence=AAX88838.1; Type=Erroneous gene model prediction; Evidence={ECO:0000305}; Sequence=BAA20794.2; Type=Miscellaneous discrepancy; Note=Wrong choice of CDS.; Evidence={ECO:0000305}; Sequence=EAW53882.1; Type=Erroneous gene model prediction; Evidence={ECO:0000305};

Annotations taken from UniProtKB at the EBI.


Organism:		Homo sapiens (Human).
Taxonomy:		Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo.



Function:		Golgin which probably tethers transport vesicles to the trans-Golgi network (TGN) and regulates vesicular transport between the endosomes and the Golgi. As a RAB9A effector it is involved in recycling of the mannose 6-phosphate receptor from the late endosomes to the TGN. May also play a role in transport between the recycling endosomes and the Golgi. Required for maintenance of the Golgi structure, it is involved in the biogenesis of noncentrosomal, Golgi- associated microtubules through recruitment of CLASP1 and CLASP2. {ECO:0000269\|PubMed:16885419, ECO:0000269\|PubMed:17488291, ECO:0000269\|PubMed:17543864}.


Subunit:		Homodimer. Interacts (via GRIP domain) with RAB6A (preferentially in its GTP-bound form). May interact (RAB6A-dependent) with ARL1; according to PubMed:19703403, RAB6A and ARL1 are not involved in GCC2 Golgi localization as proposed by PubMed:18243103. Interacts (probably via GRIP domain) with RAB9A (preferentially in its GTP-bound form). Interacts with CLASP1 and CLASP2; recruits both proteins to membranes of the TGN. Interacts with STX16. {ECO:0000269\|PubMed:16885419, ECO:0000269\|PubMed:17543864, ECO:0000269\|PubMed:18195106, ECO:0000269\|PubMed:18243103, ECO:0000269\|PubMed:19703403}.
Subcellular location:		Cytoplasm. Golgi apparatus, trans-Golgi network membrane; Peripheral membrane protein.
Tissue specificity:		Ubiquitous. {ECO:0000269\|PubMed:11149944}.
Domain:		Extended rod-like protein with coiled-coil domains.
Miscellaneous:		[Isoform 2]: May be produced at very low levels due to a premature stop codon in the mRNA, leading to nonsense-mediated mRNA decay. {ECO:0000305}.
Sequence caution:		Sequence=AAG34902.1; Type=Frameshift; Evidence={ECO:0000305}; Sequence=AAH37774.1; Type=Miscellaneous discrepancy; Note=Wrong choice of CDS.; Evidence={ECO:0000305}; Sequence=AAI46790.1; Type=Miscellaneous discrepancy; Note=Wrong choice of CDS.; Evidence={ECO:0000305}; Sequence=AAL99918.1; Type=Erroneous initiation; Note=Extended N-terminus.; Evidence={ECO:0000305}; Sequence=AAX88838.1; Type=Erroneous gene model prediction; Evidence={ECO:0000305}; Sequence=BAA20794.2; Type=Miscellaneous discrepancy; Note=Wrong choice of CDS.; Evidence={ECO:0000305}; Sequence=EAW53882.1; Type=Erroneous gene model prediction; Evidence={ECO:0000305};