UniProt functional annotation for P20340



	UniProt functional annotation for P20340

UniProt code: P20340.

Organism: Homo sapiens (Human).

Taxonomy: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo.

Function: Protein transport. Regulator of membrane traffic from the Golgi apparatus towards the endoplasmic reticulum (ER). Has a low GTPase activity. Involved in COPI-independent retrograde transport from the Golgi to the ER (PubMed:25962623). {ECO:0000269|PubMed:25962623}.

Subunit: Interacts with BICDL1; leads to its accumulation in the pericentrosomal region (By similarity). Interacts with SCYL1BP1. Interacts with VSP52 and RABGAP1. Interacts with GCC2 (via its GRIP domain). Interacts with RAB6IP1 (via its RUN 1 domain). Isoform 1 interacts with RAB6KIFL. Isoform 2 does not interact with RAB6KIFL. Isoform 1 interacts with BICD1. Isoform 2 interacts with BICD1. Isoform 1 interacts with BICD2. Isoform 2 interacts with BICD2. Interacts with TMF1. Isoform 1 (GTP-bound) interacts with DYNLRB1; the interaction is direct. Isoform 2 (GDP-bound) interacts with DYNLRB1; the interaction is direct. Interacts with PIFO. Interacts (GTP-bound) with APBA1/MINT1 isoform 2, also called Mint1_826, but not with isoform 1. Interacts with RIC1 and RGP1; the interactions are direct with a preference for RAB6A-GDP. {ECO:0000250|UniProtKB:P35279, ECO:0000269|PubMed:10202141, ECO:0000269|PubMed:12447383, ECO:0000269|PubMed:15878329, ECO:0000269|PubMed:16034420, ECO:0000269|PubMed:16332443, ECO:0000269|PubMed:17698061, ECO:0000269|PubMed:18044744, ECO:0000269|PubMed:18243103, ECO:0000269|PubMed:18997784, ECO:0000269|PubMed:19141279, ECO:0000269|PubMed:20386726, ECO:0000269|PubMed:20643351, ECO:0000269|PubMed:23091056, ECO:0000269|PubMed:23664119, ECO:0000269|PubMed:23737971, ECO:0000269|PubMed:25962623}.

Subunit: (Microbial infection) Interacts with human cytomegalovirus protein UL32. {ECO:0000269|PubMed:21411515}.

Subcellular location: Golgi apparatus membrane {ECO:0000269|PubMed:23091056, ECO:0000269|PubMed:25962623}; Lipid- anchor {ECO:0000269|PubMed:25962623}. Note=BICD2 facilitates its targeting to Golgi apparatus membrane. {ECO:0000269|PubMed:25962623}.

Subcellular location: [Isoform 1]: Golgi apparatus membrane {ECO:0000269|PubMed:11071909}; Lipid-anchor {ECO:0000305}.

Subcellular location: [Isoform 2]: Golgi apparatus membrane {ECO:0000269|PubMed:11071909}; Lipid-anchor {ECO:0000305}.

Tissue specificity: Ubiquitous. {ECO:0000269|PubMed:11071909}.

Ptm: Prenylated. {ECO:0000269|PubMed:25962623}.

Similarity: Belongs to the small GTPase superfamily. Rab family. {ECO:0000305}.

Annotations taken from UniProtKB at the EBI.


Organism:		Homo sapiens (Human).
Taxonomy:		Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo.



Function:		Protein transport. Regulator of membrane traffic from the Golgi apparatus towards the endoplasmic reticulum (ER). Has a low GTPase activity. Involved in COPI-independent retrograde transport from the Golgi to the ER (PubMed:25962623). {ECO:0000269\|PubMed:25962623}.


Subunit:		Interacts with BICDL1; leads to its accumulation in the pericentrosomal region (By similarity). Interacts with SCYL1BP1. Interacts with VSP52 and RABGAP1. Interacts with GCC2 (via its GRIP domain). Interacts with RAB6IP1 (via its RUN 1 domain). Isoform 1 interacts with RAB6KIFL. Isoform 2 does not interact with RAB6KIFL. Isoform 1 interacts with BICD1. Isoform 2 interacts with BICD1. Isoform 1 interacts with BICD2. Isoform 2 interacts with BICD2. Interacts with TMF1. Isoform 1 (GTP-bound) interacts with DYNLRB1; the interaction is direct. Isoform 2 (GDP-bound) interacts with DYNLRB1; the interaction is direct. Interacts with PIFO. Interacts (GTP-bound) with APBA1/MINT1 isoform 2, also called Mint1_826, but not with isoform 1. Interacts with RIC1 and RGP1; the interactions are direct with a preference for RAB6A-GDP. {ECO:0000250\|UniProtKB:P35279, ECO:0000269\|PubMed:10202141, ECO:0000269\|PubMed:12447383, ECO:0000269\|PubMed:15878329, ECO:0000269\|PubMed:16034420, ECO:0000269\|PubMed:16332443, ECO:0000269\|PubMed:17698061, ECO:0000269\|PubMed:18044744, ECO:0000269\|PubMed:18243103, ECO:0000269\|PubMed:18997784, ECO:0000269\|PubMed:19141279, ECO:0000269\|PubMed:20386726, ECO:0000269\|PubMed:20643351, ECO:0000269\|PubMed:23091056, ECO:0000269\|PubMed:23664119, ECO:0000269\|PubMed:23737971, ECO:0000269\|PubMed:25962623}.
Subunit:		(Microbial infection) Interacts with human cytomegalovirus protein UL32. {ECO:0000269\|PubMed:21411515}.
Subcellular location:		Golgi apparatus membrane {ECO:0000269\|PubMed:23091056, ECO:0000269\|PubMed:25962623}; Lipid- anchor {ECO:0000269\|PubMed:25962623}. Note=BICD2 facilitates its targeting to Golgi apparatus membrane. {ECO:0000269\|PubMed:25962623}.
Subcellular location:		[Isoform 1]: Golgi apparatus membrane {ECO:0000269\|PubMed:11071909}; Lipid-anchor {ECO:0000305}.
Subcellular location:		[Isoform 2]: Golgi apparatus membrane {ECO:0000269\|PubMed:11071909}; Lipid-anchor {ECO:0000305}.
Tissue specificity:		Ubiquitous. {ECO:0000269\|PubMed:11071909}.
Ptm:		Prenylated. {ECO:0000269\|PubMed:25962623}.
Similarity:		Belongs to the small GTPase superfamily. Rab family. {ECO:0000305}.