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UniProt functional annotation for Q65CJ7 | ||
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| UniProt code: Q65CJ7. |
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| Organism: | |
Plectranthus scutellarioides (Coleus) (Solenostemon scutellarioides). |
| Taxonomy: | |
Eukaryota; Viridiplantae; Streptophyta; Embryophyta; Tracheophyta; Spermatophyta; Magnoliopsida; eudicotyledons; Gunneridae; Pentapetalae; asterids; lamiids; Lamiales; Lamiaceae; Nepetoideae; Ocimeae; Plectranthus. |
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| Function: | |
Catalyzes the NAD(P)H-dependent reduction of 4- hydroxyphenylpyruvate to 4-hydroxyphenyllactate and 3,4- dihydroxyphenylpyruvate to 3,4-dihydroxyphenyllactate in the biosynthesis of rosmarinic acid. Rosmarinic acid is an ester of caffeic acid and 3,4-dihydroxyphenyllactic acid. NADP is the preferred substrate. {ECO:0000269|PubMed:15284489}. |
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| Catalytic activity: | |
Reaction=(2R)-2-hydroxy-3-(4-hydroxyphenyl)propanoate + NAD(+) = 3-(4- hydroxyphenyl)pyruvate + H(+) + NADH; Xref=Rhea:RHEA:10780, ChEBI:CHEBI:10980, ChEBI:CHEBI:15378, ChEBI:CHEBI:36242, ChEBI:CHEBI:57540, ChEBI:CHEBI:57945; EC=1.1.1.237; Evidence={ECO:0000269|PubMed:15284489}; |
| Catalytic activity: | |
Reaction=(2R)-2-hydroxy-3-(4-hydroxyphenyl)propanoate + NADP(+) = 3-(4- hydroxyphenyl)pyruvate + H(+) + NADPH; Xref=Rhea:RHEA:10776, ChEBI:CHEBI:10980, ChEBI:CHEBI:15378, ChEBI:CHEBI:36242, ChEBI:CHEBI:57783, ChEBI:CHEBI:58349; EC=1.1.1.237; Evidence={ECO:0000269|PubMed:15284489}; |
| Catalytic activity: | |
Reaction=(2R)-3-(3,4-dihydroxyphenyl)lactate + NADP(+) = 3-(3,4- dihydroxyphenyl)pyruvate + H(+) + NADPH; Xref=Rhea:RHEA:57704, ChEBI:CHEBI:15378, ChEBI:CHEBI:29055, ChEBI:CHEBI:57783, ChEBI:CHEBI:58349, ChEBI:CHEBI:71492; EC=1.1.1.237; Evidence={ECO:0000269|PubMed:15284489}; |
| Catalytic activity: | |
Reaction=(2R)-3-(3,4-dihydroxyphenyl)lactate + NAD(+) = 3-(3,4- dihydroxyphenyl)pyruvate + H(+) + NADH; Xref=Rhea:RHEA:57408, ChEBI:CHEBI:15378, ChEBI:CHEBI:29055, ChEBI:CHEBI:57540, ChEBI:CHEBI:57945, ChEBI:CHEBI:71492; EC=1.1.1.237; Evidence={ECO:0000269|PubMed:15284489}; |
| Similarity: | |
Belongs to the D-isomer specific 2-hydroxyacid dehydrogenase family. {ECO:0000305}. |
Annotations taken from UniProtKB at the EBI.