UniProt functional annotation for P05027



	UniProt functional annotation for P05027

UniProt code: P05027.

Organism: Sus scrofa (Pig).

Taxonomy: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Laurasiatheria; Artiodactyla; Suina; Suidae; Sus.

Function: This is the non-catalytic component of the active enzyme, which catalyzes the hydrolysis of ATP coupled with the exchange of Na(+) and K(+) ions across the plasma membrane. The beta subunit regulates, through assembly of alpha/beta heterodimers, the number of sodium pumps transported to the plasma membrane.

Function: Involved in cell adhesion and establishing epithelial cell polarity. {ECO:0000250}.

Subunit: The sodium/potassium-transporting ATPase is composed of a catalytic alpha subunit, an auxiliary non-catalytic beta subunit and an additional regulatory subunit. Interacts with catalytic subunit ATP12A. Interacts with regulatory subunit FXYD1. Interacts with regulatory subunit FXYD3. Interacts with NKAIN1, NKAIN2 and NKAIN4. Interacts with MLC1. Part of a complex containing MLC1, TRPV4, AQP4 and HEPACAM. Interacts with KIRREL3. Interacts with OBSCN (via protein kinase domain 1). {ECO:0000250|UniProtKB:P05026, ECO:0000250|UniProtKB:P07340, ECO:0000250|UniProtKB:P14094}.

Subcellular location: Cell membrane {ECO:0000255}; Single-pass type II membrane protein {ECO:0000255}. Apical cell membrane {ECO:0000250|UniProtKB:P07340}; Single-pass type II membrane protein {ECO:0000255}. Cell membrane, sarcolemma {ECO:0000250|UniProtKB:P14094}. Note=Colocalizes with OBSCN at the intercalated disk and sarcolemma in cardiomyocytes. Localizes in long striations at the level of Z and M lines. {ECO:0000250|UniProtKB:P14094}.

Domain: The C-terminal lobe folds into an immunoglobulin-like domain and mediates cell adhesion properties. {ECO:0000250}.

Ptm: Glutathionylated (By similarity). N-glycosylated (By similarity). {ECO:0000250|UniProtKB:P07340, ECO:0000250|UniProtKB:P14094}.

Similarity: Belongs to the X(+)/potassium ATPases subunit beta family. {ECO:0000305}.

Annotations taken from UniProtKB at the EBI.


Organism:		Sus scrofa (Pig).
Taxonomy:		Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Laurasiatheria; Artiodactyla; Suina; Suidae; Sus.



Function:		This is the non-catalytic component of the active enzyme, which catalyzes the hydrolysis of ATP coupled with the exchange of Na(+) and K(+) ions across the plasma membrane. The beta subunit regulates, through assembly of alpha/beta heterodimers, the number of sodium pumps transported to the plasma membrane.



Function:		Involved in cell adhesion and establishing epithelial cell polarity. {ECO:0000250}.


Subunit:		The sodium/potassium-transporting ATPase is composed of a catalytic alpha subunit, an auxiliary non-catalytic beta subunit and an additional regulatory subunit. Interacts with catalytic subunit ATP12A. Interacts with regulatory subunit FXYD1. Interacts with regulatory subunit FXYD3. Interacts with NKAIN1, NKAIN2 and NKAIN4. Interacts with MLC1. Part of a complex containing MLC1, TRPV4, AQP4 and HEPACAM. Interacts with KIRREL3. Interacts with OBSCN (via protein kinase domain 1). {ECO:0000250\|UniProtKB:P05026, ECO:0000250\|UniProtKB:P07340, ECO:0000250\|UniProtKB:P14094}.
Subcellular location:		Cell membrane {ECO:0000255}; Single-pass type II membrane protein {ECO:0000255}. Apical cell membrane {ECO:0000250\|UniProtKB:P07340}; Single-pass type II membrane protein {ECO:0000255}. Cell membrane, sarcolemma {ECO:0000250\|UniProtKB:P14094}. Note=Colocalizes with OBSCN at the intercalated disk and sarcolemma in cardiomyocytes. Localizes in long striations at the level of Z and M lines. {ECO:0000250\|UniProtKB:P14094}.
Domain:		The C-terminal lobe folds into an immunoglobulin-like domain and mediates cell adhesion properties. {ECO:0000250}.
Ptm:		Glutathionylated (By similarity). N-glycosylated (By similarity). {ECO:0000250\|UniProtKB:P07340, ECO:0000250\|UniProtKB:P14094}.
Similarity:		Belongs to the X(+)/potassium ATPases subunit beta family. {ECO:0000305}.