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UniProt functional annotation for P09391 | ||
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| UniProt code: P09391. |
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| Organism: | |
Escherichia coli (strain K12). |
| Taxonomy: | |
Bacteria; Proteobacteria; Gammaproteobacteria; Enterobacterales; Enterobacteriaceae; Escherichia. |
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| Function: | |
Rhomboid-type serine protease that catalyzes intramembrane proteolysis. {ECO:0000269|PubMed:16216077, ECO:0000269|PubMed:17099694}. |
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| Catalytic activity: | |
Reaction=Cleaves type-1 transmembrane domains using a catalytic dyad composed of serine and histidine that are contributed by different transmembrane domains.; EC=3.4.21.105; |
| Subcellular location: | |
Cell inner membrane {ECO:0000269|PubMed:16216077}; Multi-pass membrane protein {ECO:0000269|PubMed:16216077}. |
| Domain: | |
The loop between transmembrane domains 5 and 6 is flexible and may readily open to the extracellular side to allow water entry into the active site cavity. {ECO:0000269|PubMed:17099694}. |
| Similarity: | |
Belongs to the peptidase S54 family. {ECO:0000305}. |
| Sequence caution: | |
Sequence=AAA58222.1; Type=Erroneous initiation; Evidence={ECO:0000305}; |
Annotations taken from UniProtKB at the EBI.