UniProt functional annotation for P0DJH6



	UniProt functional annotation for P0DJH6

UniProt code: P0DJH6.

Organism: Gallus gallus (Chicken).

Taxonomy: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Archelosauria; Archosauria; Dinosauria; Saurischia; Theropoda; Coelurosauria; Aves; Neognathae; Galloanserae; Galliformes; Phasianidae; Phasianinae; Gallus.

Function: Component of the CENPA-NAC (nucleosome-associated) complex, a complex that plays a central role in assembly of kinetochore proteins, mitotic progression and chromosome segregation (By similarity). The CENPA-NAC complex recruits the CENPA-CAD (nucleosome distal) complex and may be involved in incorporation of newly synthesized CENPA into centromeres (By similarity). Part of a nucleosome-associated complex that binds specifically to histone H3-containing nucleosomes at the centromere, as opposed to nucleosomes containing CENPA. Component of the heterotetrameric CENP-T-W-S-X complex that binds and supercoils DNA, and plays an important role in kinetochore assembly. CENPW has a fundamental role in kinetochore assembly and function. It is one of the inner kinetochore proteins, with most further proteins binding downstream. Required for normal chromosome organization and normal progress through mitosis. {ECO:0000250, ECO:0000269|PubMed:19070575, ECO:0000269|PubMed:22304917}.

Subunit: Heterodimer with CENPT; this dimer coassembles with CENPS- CENPX heterodimers at centromeres to form the tetrameric CENP-T-W-S-X complex, which is a subcomplex of the large constitutive centromere- associated network (CCAN, also known as the interphase centromere complex or ICEN) (PubMed:19070575, PubMed:21464230, PubMed:22304917). Interacts with NPM1 (By similarity). {ECO:0000250|UniProtKB:Q5EE01, ECO:0000269|PubMed:19070575, ECO:0000269|PubMed:21464230, ECO:0000269|PubMed:22304917}.

Subcellular location: Nucleus {ECO:0000269|PubMed:19070575}. Chromosome, centromere {ECO:0000269|PubMed:19070575}. Chromosome, centromere, kinetochore {ECO:0000269|PubMed:19070575}. Note=Constitutively localizes to centromeres throughout the cell cycle, and to kinetochores during mitosis (PubMed:19070575). Localizes to the inner kinetochore. {ECO:0000269|PubMed:19070575}.

Miscellaneous: Association with CENPA-containing complexes may be indirect and due to the proximity of centromeric nucleosomes containing histone H3 with those containing CENPA.

Similarity: Belongs to the CENP-W/WIP1 family. {ECO:0000305}.

Annotations taken from UniProtKB at the EBI.


Organism:		Gallus gallus (Chicken).
Taxonomy:		Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Archelosauria; Archosauria; Dinosauria; Saurischia; Theropoda; Coelurosauria; Aves; Neognathae; Galloanserae; Galliformes; Phasianidae; Phasianinae; Gallus.



Function:		Component of the CENPA-NAC (nucleosome-associated) complex, a complex that plays a central role in assembly of kinetochore proteins, mitotic progression and chromosome segregation (By similarity). The CENPA-NAC complex recruits the CENPA-CAD (nucleosome distal) complex and may be involved in incorporation of newly synthesized CENPA into centromeres (By similarity). Part of a nucleosome-associated complex that binds specifically to histone H3-containing nucleosomes at the centromere, as opposed to nucleosomes containing CENPA. Component of the heterotetrameric CENP-T-W-S-X complex that binds and supercoils DNA, and plays an important role in kinetochore assembly. CENPW has a fundamental role in kinetochore assembly and function. It is one of the inner kinetochore proteins, with most further proteins binding downstream. Required for normal chromosome organization and normal progress through mitosis. {ECO:0000250, ECO:0000269\|PubMed:19070575, ECO:0000269\|PubMed:22304917}.


Subunit:		Heterodimer with CENPT; this dimer coassembles with CENPS- CENPX heterodimers at centromeres to form the tetrameric CENP-T-W-S-X complex, which is a subcomplex of the large constitutive centromere- associated network (CCAN, also known as the interphase centromere complex or ICEN) (PubMed:19070575, PubMed:21464230, PubMed:22304917). Interacts with NPM1 (By similarity). {ECO:0000250\|UniProtKB:Q5EE01, ECO:0000269\|PubMed:19070575, ECO:0000269\|PubMed:21464230, ECO:0000269\|PubMed:22304917}.
Subcellular location:		Nucleus {ECO:0000269\|PubMed:19070575}. Chromosome, centromere {ECO:0000269\|PubMed:19070575}. Chromosome, centromere, kinetochore {ECO:0000269\|PubMed:19070575}. Note=Constitutively localizes to centromeres throughout the cell cycle, and to kinetochores during mitosis (PubMed:19070575). Localizes to the inner kinetochore. {ECO:0000269\|PubMed:19070575}.
Miscellaneous:		Association with CENPA-containing complexes may be indirect and due to the proximity of centromeric nucleosomes containing histone H3 with those containing CENPA.
Similarity:		Belongs to the CENP-W/WIP1 family. {ECO:0000305}.