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PDBsum entry 3aos
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Hormone binding protein
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PDB id
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3aos
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References listed in PDB file
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Key reference
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Title
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Structural mechanism of jh delivery in hemolymph by jhbp of silkworm, Bombyx mori.
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Authors
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R.Suzuki,
Z.Fujimoto,
T.Shiotsuki,
W.Tsuchiya,
M.Momma,
A.Tase,
M.Miyazawa,
T.Yamazaki.
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Ref.
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Sci Rep, 2011,
1,
133.
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PubMed id
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Abstract
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Juvenile hormone (JH) plays crucial roles in many aspects of the insect life.
All the JH actions are initiated by transport of JH in the hemolymph as a
complex with JH-binding protein (JHBP) to target tissues. Here, we report
structural mechanism of JH delivery by JHBP based upon the crystal and solution
structures of apo and JH-bound JHBP. In solution, apo-JHBP exists in equilibrium
of multiple conformations with different orientations of the gate helix for the
hormone-binding pocket ranging from closed to open forms. JH-binding to the
gate-open form results in the fully closed JHBP-JH complex structure where the
bound JH is completely buried inside the protein. JH-bound JHBP opens the gate
helix to release the bound hormone likely by sensing the less polar environment
at the membrane surface of target cells. This is the first report that provides
structural insight into JH signaling.
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Secondary reference #1
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Title
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Nmr assignments of juvenile hormone binding protein in complex with jh III.
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Authors
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R.Suzuki,
A.Tase,
Z.Fujimoto,
T.Shiotsuki,
T.Yamazaki.
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Ref.
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Biomol Nmr Assign, 2009,
3,
73-76.
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PubMed id
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