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UniProt functional annotation for P12104 | ||
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| UniProt code: P12104. |
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| Organism: | |
Homo sapiens (Human). |
| Taxonomy: | |
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo. |
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| Function: | |
FABP are thought to play a role in the intracellular transport of long-chain fatty acids and their acyl-CoA esters. FABP2 is probably involved in triglyceride-rich lipoprotein synthesis. Binds saturated long-chain fatty acids with a high affinity, but binds with a lower affinity to unsaturated long-chain fatty acids. FABP2 may also help maintain energy homeostasis by functioning as a lipid sensor. |
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| Subcellular location: | |
Cytoplasm. |
| Tissue specificity: | |
Expressed in the small intestine and at much lower levels in the large intestine. Highest expression levels in the jejunum. {ECO:0000269|PubMed:14563446}. |
| Induction: | |
By EGF. {ECO:0000269|PubMed:10070036}. |
| Domain: | |
Forms a beta-barrel structure that accommodates the hydrophobic ligand in its interior. |
| Similarity: | |
Belongs to the calycin superfamily. Fatty-acid binding protein (FABP) family. {ECO:0000305}. |
Annotations taken from UniProtKB at the EBI.