UniProt functional annotation for Q0QF01



	UniProt functional annotation for Q0QF01

UniProt code: Q0QF01.

Organism: Sus scrofa (Pig).

Taxonomy: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Laurasiatheria; Artiodactyla; Suina; Suidae; Sus.

Function: Flavoprotein (FP) subunit of succinate dehydrogenase (SDH) that is involved in complex II of the mitochondrial electron transport chain and is responsible for transferring electrons from succinate to ubiquinone (coenzyme Q) (Probable). Can act as a tumor suppressor (By similarity). {ECO:0000250|UniProtKB:P31040, ECO:0000305|PubMed:15989954}.

Catalytic activity: Reaction=a quinone + succinate = a quinol + fumarate; Xref=Rhea:RHEA:40523, ChEBI:CHEBI:24646, ChEBI:CHEBI:29806, ChEBI:CHEBI:30031, ChEBI:CHEBI:132124; EC=1.3.5.1; Evidence={ECO:0000305|PubMed:15989954};

Cofactor: Name=FAD; Xref=ChEBI:CHEBI:57692; Evidence={ECO:0000269|PubMed:15989954};

Pathway: Carbohydrate metabolism; tricarboxylic acid cycle; fumarate from succinate (eukaryal route): step 1/1. {ECO:0000305|PubMed:15989954}.

Subunit: Component of complex II composed of four subunits: the flavoprotein (FP) SDHA, iron-sulfur protein (IP) SDHB, and a cytochrome b560 composed of SDHC and SDHD (PubMed:15989954, PubMed:17480203). Interacts with SDHAF2/SDH5; interaction is required for FAD attachment (By similarity). Interacts with TRAP1 (By similarity). Interacts with LACC1 (By similarity). {ECO:0000250|UniProtKB:P31040, ECO:0000269|PubMed:15989954, ECO:0000269|PubMed:17480203}.

Subcellular location: Mitochondrion inner membrane {ECO:0000269|PubMed:17480203}; Peripheral membrane protein {ECO:0000269|PubMed:17480203}; Matrix side {ECO:0000269|PubMed:17480203}.

Ptm: Phosphorylation at Tyr-215 is important for efficient electron transfer in complex II and the prevention of ROS generation. {ECO:0000250|UniProtKB:P31040}.

Ptm: Acetylated. Deacetylated by SIRT3. {ECO:0000250|UniProtKB:Q8K2B3}.

Similarity: Belongs to the FAD-dependent oxidoreductase 2 family. FRD/SDH subfamily. {ECO:0000305}.

Sequence caution: Sequence=ABI29191.1; Type=Erroneous initiation; Evidence={ECO:0000305};

Annotations taken from UniProtKB at the EBI.


Organism:		Sus scrofa (Pig).
Taxonomy:		Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Laurasiatheria; Artiodactyla; Suina; Suidae; Sus.



Function:		Flavoprotein (FP) subunit of succinate dehydrogenase (SDH) that is involved in complex II of the mitochondrial electron transport chain and is responsible for transferring electrons from succinate to ubiquinone (coenzyme Q) (Probable). Can act as a tumor suppressor (By similarity). {ECO:0000250\|UniProtKB:P31040, ECO:0000305\|PubMed:15989954}.


Catalytic activity:		Reaction=a quinone + succinate = a quinol + fumarate; Xref=Rhea:RHEA:40523, ChEBI:CHEBI:24646, ChEBI:CHEBI:29806, ChEBI:CHEBI:30031, ChEBI:CHEBI:132124; EC=1.3.5.1; Evidence={ECO:0000305\|PubMed:15989954};
Cofactor:		Name=FAD; Xref=ChEBI:CHEBI:57692; Evidence={ECO:0000269\|PubMed:15989954};
Pathway:		Carbohydrate metabolism; tricarboxylic acid cycle; fumarate from succinate (eukaryal route): step 1/1. {ECO:0000305\|PubMed:15989954}.
Subunit:		Component of complex II composed of four subunits: the flavoprotein (FP) SDHA, iron-sulfur protein (IP) SDHB, and a cytochrome b560 composed of SDHC and SDHD (PubMed:15989954, PubMed:17480203). Interacts with SDHAF2/SDH5; interaction is required for FAD attachment (By similarity). Interacts with TRAP1 (By similarity). Interacts with LACC1 (By similarity). {ECO:0000250\|UniProtKB:P31040, ECO:0000269\|PubMed:15989954, ECO:0000269\|PubMed:17480203}.
Subcellular location:		Mitochondrion inner membrane {ECO:0000269\|PubMed:17480203}; Peripheral membrane protein {ECO:0000269\|PubMed:17480203}; Matrix side {ECO:0000269\|PubMed:17480203}.
Ptm:		Phosphorylation at Tyr-215 is important for efficient electron transfer in complex II and the prevention of ROS generation. {ECO:0000250\|UniProtKB:P31040}.
Ptm:		Acetylated. Deacetylated by SIRT3. {ECO:0000250\|UniProtKB:Q8K2B3}.
Similarity:		Belongs to the FAD-dependent oxidoreductase 2 family. FRD/SDH subfamily. {ECO:0000305}.
Sequence caution:		Sequence=ABI29191.1; Type=Erroneous initiation; Evidence={ECO:0000305};