|
|
||
|
|
|
|
|
UniProt functional annotation for Q007T0 | ||
|
|
|
|
|
|
||
| UniProt code: Q007T0. |
|
||
| Organism: | |
Sus scrofa (Pig). |
| Taxonomy: | |
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Laurasiatheria; Artiodactyla; Suina; Suidae; Sus. |
|
||
|
||
| Function: | |
Iron-sulfur protein (IP) subunit of succinate dehydrogenase (SDH) that is involved in complex II of the mitochondrial electron transport chain and is responsible for transferring electrons from succinate to ubiquinone (coenzyme Q). |
|
||
| Catalytic activity: | |
Reaction=a quinone + succinate = a quinol + fumarate; Xref=Rhea:RHEA:40523, ChEBI:CHEBI:24646, ChEBI:CHEBI:29806, ChEBI:CHEBI:30031, ChEBI:CHEBI:132124; EC=1.3.5.1; |
| Cofactor: | |
Name=[2Fe-2S] cluster; Xref=ChEBI:CHEBI:49601; Note=Binds 1 [2Fe-2S] cluster.; |
| Cofactor: | |
Name=[3Fe-4S] cluster; Xref=ChEBI:CHEBI:21137; Note=Binds 1 [3Fe-4S] cluster.; |
| Cofactor: | |
Name=[4Fe-4S] cluster; Xref=ChEBI:CHEBI:49883; Note=Binds 1 [4Fe-4S] cluster.; |
| Pathway: | |
Carbohydrate metabolism; tricarboxylic acid cycle; fumarate from succinate (eukaryal route): step 1/1. |
| Subunit: | |
Component of complex II composed of four subunits: the flavoprotein (FP) SDHA, iron-sulfur protein (IP) SDHB, and a cytochrome b560 composed of SDHC and SDHD (PubMed:15989954). Interacts with SDHAF1; the interaction is required for iron-sulfur cluster incorporation into SDHB (By similarity). {ECO:0000250|UniProtKB:P21912, ECO:0000269|PubMed:15989954}. |
| Subcellular location: | |
Mitochondrion inner membrane {ECO:0000250}; Peripheral membrane protein {ECO:0000250}; Matrix side {ECO:0000250}. |
| Similarity: | |
Belongs to the succinate dehydrogenase/fumarate reductase iron-sulfur protein family. {ECO:0000305}. |
Annotations taken from UniProtKB at the EBI.