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UniProt functional annotation for O29777 | ||
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| UniProt code: O29777. |
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| Organism: | |
Archaeoglobus fulgidus (strain ATCC 49558 / VC-16 / DSM 4304 / JCM 9628 / NBRC 100126). |
| Taxonomy: | |
Archaea; Euryarchaeota; Archaeoglobi; Archaeoglobales; Archaeoglobaceae; Archaeoglobus. |
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| Function: | |
Probably involved in copper and silver export. {ECO:0000269|PubMed:11756450}. |
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| Catalytic activity: | |
Reaction=ATP + Cu(+)(in) + H2O = ADP + Cu(+)(out) + H(+) + phosphate; Xref=Rhea:RHEA:25792, ChEBI:CHEBI:15377, ChEBI:CHEBI:15378, ChEBI:CHEBI:30616, ChEBI:CHEBI:43474, ChEBI:CHEBI:49552, ChEBI:CHEBI:456216; EC=7.2.2.8; Evidence={ECO:0000269|PubMed:16495228}; |
| Activity regulation: | |
Activated by Cu(+) and Ag(+) and inhibited by vanadate. Activated by CopZ in its Cu(+)-bound form. {ECO:0000269|PubMed:11756450, ECO:0000269|PubMed:12763798}. |
| Biophysicochemical properties: | |
Kinetic parameters: KM=0.25 mM for ATP {ECO:0000269|PubMed:11756450, ECO:0000269|PubMed:12763798}; Vmax=14.9 umol/h/mg enzyme with Ag(+) as substrate {ECO:0000269|PubMed:11756450, ECO:0000269|PubMed:12763798}; Vmax=3.7 umol/h/mg enzyme with Cu(+) as substrate {ECO:0000269|PubMed:11756450, ECO:0000269|PubMed:12763798}; Note=Shows higher affinity for Cu(+) compared with Ag(+).; pH dependence: Optimum pH is 6.1-6.5. {ECO:0000269|PubMed:11756450, ECO:0000269|PubMed:12763798}; Temperature dependence: Optimum temperature is 75 degrees Celsius. {ECO:0000269|PubMed:11756450, ECO:0000269|PubMed:12763798}; |
| Subunit: | |
Interacts with CopZ probably in the CopZ Cu(+)-bound form. {ECO:0000269|PubMed:18417453}. |
| Subcellular location: | |
Cell membrane; Multi-pass membrane protein. |
| Similarity: | |
Belongs to the cation transport ATPase (P-type) (TC 3.A.3) family. Type IB subfamily. {ECO:0000305}. |
Annotations taken from UniProtKB at the EBI.