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PDBsum entry 3t3l
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protein ligands links
Oxidoreductase PDB id
3t3l

 

 

 

 

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JSmol PyMol  
Contents
Protein chain
121 a.a.
Ligands
SO4
Waters ×94
PDB id:
3t3l
Name: Oxidoreductase
Title: 1.15 a structure of human frataxin variant q153a
Structure: Frataxin, mitochondrial. Chain: a. Fragment: mature form (unp residues 82-210). Synonym: friedreich ataxia protein, fxn. Engineered: yes. Mutation: yes
Source: Homo sapiens. Human. Organism_taxid: 9606. Gene: fxn, frda, x25. Expressed in: escherichia coli. Expression_system_taxid: 562
Resolution:
1.15Å     R-factor:   0.167     R-free:   0.179
Authors: J.Bridwell-Rabb,A.M.Winn,D.P.Barondeau
Key ref: J.Bridwell-Rabb et al. (2011). Structure-function analysis of Friedreich's ataxia mutants reveals determinants of frataxin binding and activation of the Fe-S assembly complex. Biochemistry, 50, 7265-7274. PubMed id: 21776984
Date:
25-Jul-11     Release date:   10-Aug-11    
PROCHECK
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 Headers
 References

Protein chain
Pfam   ArchSchema ?
Q16595  (FRDA_HUMAN) -  Frataxin, mitochondrial from Homo sapiens
Seq:
Struc: 		210 a.a.
121 a.a.*
Key:    PfamA domain  Secondary structure  CATH domain
* PDB and UniProt seqs differ at 1 residue position (black cross)

 Enzyme reactions 
   Enzyme class: E.C.1.16.3.1  - ferroxidase.
[IntEnz]   [ExPASy]   [KEGG]   [BRENDA]
      Reaction: 4 Fe2+ + O2 + 4 H+ = 4 Fe3+ + 2 H2O
4 × Fe(2+)
 + O2
 + 4 × H(+)
 = 4 × Fe(3+)
 + 2 × H2O
      Cofactor: Cu cation
Molecule diagrams generated from .mol files obtained from the KEGG ftp site

 

 
    Key reference    
 
 
Biochemistry 50:7265-7274 (2011)
PubMed id: 21776984  
 
 
Structure-function analysis of Friedreich's ataxia mutants reveals determinants of frataxin binding and activation of the Fe-S assembly complex.
J.Bridwell-Rabb, A.M.Winn, D.P.Barondeau.
 
  ABSTRACT  
 
No abstract given.

 

 

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