|
|
||
|
|
|
|
|
UniProt functional annotation for Q9M6E9 | ||
|
|
|
|
|
|
||
| UniProt code: Q9M6E9. |
|
||
| Organism: | |
Abrus precatorius (Indian licorice) (Glycine abrus). |
| Taxonomy: | |
Eukaryota; Viridiplantae; Streptophyta; Embryophyta; Tracheophyta; Spermatophyta; Magnoliopsida; eudicotyledons; Gunneridae; Pentapetalae; rosids; fabids; Fabales; Fabaceae; Papilionoideae; 50 kb inversion clade; NPAAA clade; indigoferoid/millettioid clade; Abreae; Abrus. |
|
||
|
||
| Function: | |
The A chain is responsible for inhibiting protein synthesis through the catalytic inactivation of 60S ribosomal subunits by removing adenine from position 4,324 of 28S rRNA (By similarity). Less toxic than abrin-a. {ECO:0000250|UniProtKB:P28590, ECO:0000269|PubMed:10636890}. |
|
||
|
||
| Function: | |
The B chain is a galactose-specific lectin that facilitates the binding to the cell membrane that precedes endocytosis. {ECO:0000250|UniProtKB:P28590}. |
|
||
| Catalytic activity: | |
Reaction=Endohydrolysis of the N-glycosidic bond at one specific adenosine on the 28S rRNA.; EC=3.2.2.22; Evidence={ECO:0000250|UniProtKB:P11140}; |
| Subunit: | |
Heterotetramer of two A and two B chains. {ECO:0000269|PubMed:16772301}. |
| Domain: | |
The B chain is composed of two domains, each domain consists of 3 homologous subdomains (alpha, beta, gamma). {ECO:0000255}. |
| Miscellaneous: | |
Induces cytokine production and proliferation of splenocytes and thymocytes in mice. {ECO:0000269|PubMed:15474989}. |
| Similarity: | |
In the N-terminal section; belongs to the ribosome- inactivating protein family. Type 2 RIP subfamily. {ECO:0000255}. |
Annotations taken from UniProtKB at the EBI.