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PDBsum entry 2zmv
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Transport protein
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PDB id
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2zmv
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References listed in PDB file
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Key reference
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Title
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Crystal structure of human synbindin reveals two conformations of longin domain.
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Authors
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S.Fan,
Z.Wei,
H.Xu,
W.Gong.
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Ref.
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Biochem Biophys Res Commun, 2009,
378,
338-343.
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PubMed id
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Abstract
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Transport protein particle (TRAPP) is a large multiprotein complex that involves
in ER-to-Golgi and intra-Golgi traffic. Synbindin, the human ortholog of yeast
Trs23, is one component of the TRAPP complexes. In the hippocampal neurons the
synbindin/syndecan complex is involved in synaptic membrane trafficking and
thereby regulates the formation of dendritic spines. Here we present the
three-dimensional structure of human synbindin, which contains a longin domain
(LD) and an atypical PDZ domain (APD). In the crystal, synbindin forms a
hexamer, in which the LD forms two different conformations and the APD is quite
disordered. These conformational changes of synbindin suggest a possible
interaction mode of the LD.
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