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UniProt functional annotation for P51124 | ||
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| UniProt code: P51124. |
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| Organism: | |
Homo sapiens (Human). |
| Taxonomy: | |
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo. |
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| Function: | |
Cleaves peptide substrates after methionine, leucine, and norleucine. Physiological substrates include EZR, alpha-tubulins and the apoptosis inhibitor BIRC5/Survivin. Promotes caspase activation and subsequent apoptosis of target cells. {ECO:0000269|PubMed:18523284, ECO:0000269|PubMed:20406824}. |
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| Subcellular location: | |
Secreted. Cytoplasmic granule. Note=Granules of large granular lymphocytes. |
| Tissue specificity: | |
Highly and constitutively expressed in activated natural killer (NK) cells. {ECO:0000269|PubMed:18523284}. |
| Similarity: | |
Belongs to the peptidase S1 family. Granzyme subfamily. {ECO:0000255|PROSITE-ProRule:PRU00274}. |
Annotations taken from UniProtKB at the EBI.