UniProt functional annotation for P31356



	UniProt functional annotation for P31356

UniProt code: P31356.

Organism: Todarodes pacificus (Japanese flying squid) (Ommastrephes pacificus).

Taxonomy: Eukaryota; Metazoa; Spiralia; Lophotrochozoa; Mollusca; Cephalopoda; Coleoidea; Decapodiformes; Teuthida; Oegopsina; Ommastrephidae; Todarodes.

Function: Photoreceptor required for image-forming vision at low light intensity (Probable). Light-induced isomerization of 11-cis to all- trans retinal triggers a conformational change that activates signaling via G-proteins. Signaling mediates the activation of phospholipase C (Probable). Subsequent receptor phosphorylation mediates displacement of the bound G-protein alpha subunit by arrestin and terminates signaling (By similarity). {ECO:0000250|UniProtKB:P08100, ECO:0000305, ECO:0000305|PubMed:17554166, ECO:0000305|PubMed:18463093, ECO:0000305|PubMed:18480818, ECO:0000305|PubMed:21906602, ECO:0000305|PubMed:26024518}.

Subcellular location: Membrane {ECO:0000269|PubMed:17554166, ECO:0000269|PubMed:18463093, ECO:0000269|PubMed:18480818, ECO:0000269|PubMed:21906602, ECO:0000269|PubMed:26024518}; Multi-pass membrane protein {ECO:0000269|PubMed:18463093, ECO:0000269|PubMed:18480818, ECO:0000269|PubMed:21906602, ECO:0000269|PubMed:26024518}. Note=Detected on the rhabdomere membrane in the photoreceptor outer segment. {ECO:0000269|PubMed:17554166, ECO:0000269|PubMed:18463093, ECO:0000269|PubMed:18480818, ECO:0000269|PubMed:21906602}.

Tissue specificity: Retina, rhabdomere membrane (at protein level). {ECO:0000269|PubMed:17554166, ECO:0000269|PubMed:18463093, ECO:0000269|PubMed:18480818}.

Ptm: Contains one covalently linked retinal chromophore. Upon light absorption, the covalently bound 11-cis-retinal is converted to all- trans-retinal (PubMed:3191148, PubMed:17554166, PubMed:18463093, PubMed:18480818, PubMed:21906602). After hydrolysis of the Schiff base and release of the covalently bound all-trans-retinal, active rhodopsin is regenerated by binding of a fresh molecule of 11-cis-retinal (By similarity). {ECO:0000250|UniProtKB:P02699, ECO:0000269|PubMed:18463093, ECO:0000269|PubMed:18480818, ECO:0000269|PubMed:21906602, ECO:0000269|PubMed:26024518, ECO:0000269|PubMed:3191148}.

Similarity: Belongs to the G-protein coupled receptor 1 family. Opsin subfamily. {ECO:0000255|PROSITE-ProRule:PRU00521}.

Annotations taken from UniProtKB at the EBI.


Organism:		Todarodes pacificus (Japanese flying squid) (Ommastrephes pacificus).
Taxonomy:		Eukaryota; Metazoa; Spiralia; Lophotrochozoa; Mollusca; Cephalopoda; Coleoidea; Decapodiformes; Teuthida; Oegopsina; Ommastrephidae; Todarodes.



Function:		Photoreceptor required for image-forming vision at low light intensity (Probable). Light-induced isomerization of 11-cis to all- trans retinal triggers a conformational change that activates signaling via G-proteins. Signaling mediates the activation of phospholipase C (Probable). Subsequent receptor phosphorylation mediates displacement of the bound G-protein alpha subunit by arrestin and terminates signaling (By similarity). {ECO:0000250\|UniProtKB:P08100, ECO:0000305, ECO:0000305\|PubMed:17554166, ECO:0000305\|PubMed:18463093, ECO:0000305\|PubMed:18480818, ECO:0000305\|PubMed:21906602, ECO:0000305\|PubMed:26024518}.


Subcellular location:		Membrane {ECO:0000269\|PubMed:17554166, ECO:0000269\|PubMed:18463093, ECO:0000269\|PubMed:18480818, ECO:0000269\|PubMed:21906602, ECO:0000269\|PubMed:26024518}; Multi-pass membrane protein {ECO:0000269\|PubMed:18463093, ECO:0000269\|PubMed:18480818, ECO:0000269\|PubMed:21906602, ECO:0000269\|PubMed:26024518}. Note=Detected on the rhabdomere membrane in the photoreceptor outer segment. {ECO:0000269\|PubMed:17554166, ECO:0000269\|PubMed:18463093, ECO:0000269\|PubMed:18480818, ECO:0000269\|PubMed:21906602}.
Tissue specificity:		Retina, rhabdomere membrane (at protein level). {ECO:0000269\|PubMed:17554166, ECO:0000269\|PubMed:18463093, ECO:0000269\|PubMed:18480818}.
Ptm:		Contains one covalently linked retinal chromophore. Upon light absorption, the covalently bound 11-cis-retinal is converted to all- trans-retinal (PubMed:3191148, PubMed:17554166, PubMed:18463093, PubMed:18480818, PubMed:21906602). After hydrolysis of the Schiff base and release of the covalently bound all-trans-retinal, active rhodopsin is regenerated by binding of a fresh molecule of 11-cis-retinal (By similarity). {ECO:0000250\|UniProtKB:P02699, ECO:0000269\|PubMed:18463093, ECO:0000269\|PubMed:18480818, ECO:0000269\|PubMed:21906602, ECO:0000269\|PubMed:26024518, ECO:0000269\|PubMed:3191148}.
Similarity:		Belongs to the G-protein coupled receptor 1 family. Opsin subfamily. {ECO:0000255\|PROSITE-ProRule:PRU00521}.