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UniProt functional annotation for Q5SJP8 | ||
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| UniProt code: Q5SJP8. |
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| Organism: | |
Thermus thermophilus (strain ATCC 27634 / DSM 579 / HB8). |
| Taxonomy: | |
Bacteria; Deinococcus-Thermus; Deinococci; Thermales; Thermaceae; Thermus. |
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| Function: | |
Utilizes FADH(2) supplied by HpaC, to catalyze the hydroxylation of 4-hydroxyphenylacetic acid, leading to the production of 3,4-dihydroxyphenylacetic acid (DHPA). {ECO:0000269|PubMed:17804419}. |
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| Catalytic activity: | |
Reaction=4-hydroxyphenylacetate + FADH2 + O2 = 3,4- dihydroxyphenylacetate + FAD + H(+) + H2O; Xref=Rhea:RHEA:30595, ChEBI:CHEBI:15377, ChEBI:CHEBI:15378, ChEBI:CHEBI:15379, ChEBI:CHEBI:17612, ChEBI:CHEBI:48999, ChEBI:CHEBI:57692, ChEBI:CHEBI:58307; EC=1.14.14.9; Evidence={ECO:0000269|PubMed:17804419}; |
| Pathway: | |
Aromatic compound metabolism; 4-hydroxyphenylacetate degradation; pyruvate and succinate semialdehyde from 4- hydroxyphenylacetate: step 1/7. |
| Subunit: | |
Homotetramer consisting of a dimer of dimers. 4-HPA 3- monooxygenase consists of a reductase component HpaC and an oxygenase component HpaB. {ECO:0000269|PubMed:17804419}. |
| Similarity: | |
Belongs to the FADH(2)-utilizing monooxygenase family. {ECO:0000305}. |
Annotations taken from UniProtKB at the EBI.