UniProt functional annotation for Q1H9T6



	UniProt functional annotation for Q1H9T6

UniProt code: Q1H9T6.

Organism: Mus musculus (Mouse).

Taxonomy: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus.

Function: Telomere-binding protein that acts as a regulator of telomere length. Directly binds the telomeric double-stranded 5'-TTAGGG-3' repeat. Preferentially binds to telomeres that have a low concentration of shelterin complex and acts as a regulator of telomere length by initiating telomere trimming, a process that prevents the accumulation of aberrantly long telomeres. Also acts as a transcription regulator that binds to promoter regions. Regulates expression of a small subset of genes, including MTFP1. Regulates expression the J and/or S elements in MHC II promoter. Acts as a negative regulator of cell proliferation by specifically activating expression of ARF, a tumor suppressor isoform of CDKN2A. {ECO:0000250|UniProtKB:P10074}.

Subunit: Interacts with EP300. {ECO:0000250|UniProtKB:P10074}.

Subcellular location: Nucleus {ECO:0000250|UniProtKB:P10074}. Chromosome, telomere {ECO:0000250|UniProtKB:P10074}. Note=Directly binds the telomeric double-stranded 5'-TTAGGG-3' repeat. According to a report, preferentially binds to long telomeres that have a low concentration of shelterin complex, competing with the telomeric repeat binding factors TERF1 and TERF2. According to another report, binds telomeres regardless of their length. {ECO:0000250|UniProtKB:P10074}.

Domain: The C2H2-type zinc fingers mediate binding to the telomeric double-stranded 5'-TTAGGG-3' repeats. The last C2H2-type zinc finger is required for telomeric-binding. {ECO:0000250|UniProtKB:P10074}.

Miscellaneous: [Isoform 2]: May be produced at very low levels due to a premature stop codon in the mRNA, leading to nonsense-mediated mRNA decay. {ECO:0000305}.

Similarity: Belongs to the krueppel C2H2-type zinc-finger protein family. {ECO:0000305}.

Sequence caution: Sequence=CAM24576.2; Type=Erroneous gene model prediction; Evidence={ECO:0000305};

Annotations taken from UniProtKB at the EBI.


Organism:		Mus musculus (Mouse).
Taxonomy:		Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus.



Function:		Telomere-binding protein that acts as a regulator of telomere length. Directly binds the telomeric double-stranded 5'-TTAGGG-3' repeat. Preferentially binds to telomeres that have a low concentration of shelterin complex and acts as a regulator of telomere length by initiating telomere trimming, a process that prevents the accumulation of aberrantly long telomeres. Also acts as a transcription regulator that binds to promoter regions. Regulates expression of a small subset of genes, including MTFP1. Regulates expression the J and/or S elements in MHC II promoter. Acts as a negative regulator of cell proliferation by specifically activating expression of ARF, a tumor suppressor isoform of CDKN2A. {ECO:0000250\|UniProtKB:P10074}.


Subunit:		Interacts with EP300. {ECO:0000250\|UniProtKB:P10074}.
Subcellular location:		Nucleus {ECO:0000250\|UniProtKB:P10074}. Chromosome, telomere {ECO:0000250\|UniProtKB:P10074}. Note=Directly binds the telomeric double-stranded 5'-TTAGGG-3' repeat. According to a report, preferentially binds to long telomeres that have a low concentration of shelterin complex, competing with the telomeric repeat binding factors TERF1 and TERF2. According to another report, binds telomeres regardless of their length. {ECO:0000250\|UniProtKB:P10074}.
Domain:		The C2H2-type zinc fingers mediate binding to the telomeric double-stranded 5'-TTAGGG-3' repeats. The last C2H2-type zinc finger is required for telomeric-binding. {ECO:0000250\|UniProtKB:P10074}.
Miscellaneous:		[Isoform 2]: May be produced at very low levels due to a premature stop codon in the mRNA, leading to nonsense-mediated mRNA decay. {ECO:0000305}.
Similarity:		Belongs to the krueppel C2H2-type zinc-finger protein family. {ECO:0000305}.
Sequence caution:		Sequence=CAM24576.2; Type=Erroneous gene model prediction; Evidence={ECO:0000305};