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UniProt functional annotation for P82974 | ||
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| UniProt code: P82974. |
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| Organism: | |
Citrobacter freundii. |
| Taxonomy: | |
Bacteria; Proteobacteria; Gammaproteobacteria; Enterobacterales; Enterobacteriaceae; Citrobacter; Citrobacter freundii complex. |
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| Function: | |
Involved in cell wall peptidoglycan recycling (PubMed:14507260). Specifically cleaves the amide bond between the lactyl group of N-acetylmuramic acid and the alpha-amino group of the L-alanine in degradation products containing an anhydro N-acetylmuramyl moiety (PubMed:14507260). Is also involved in beta-lactamase induction (PubMed:8383940). {ECO:0000269|PubMed:14507260, ECO:0000269|PubMed:8383940}. |
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| Catalytic activity: | |
Reaction=Hydrolyzes the link between N-acetylmuramoyl residues and L- amino acid residues in certain cell-wall glycopeptides.; EC=3.5.1.28; Evidence={ECO:0000269|PubMed:14507260}; |
| Cofactor: | |
Name=Zn(2+); Xref=ChEBI:CHEBI:29105; Evidence={ECO:0000269|PubMed:12654266, ECO:0000269|PubMed:14507260}; Note=Zn(2+) is required for amidase activity. {ECO:0000269|PubMed:14507260}; |
| Activity regulation: | |
Amidase activity is inhibited by metal chelators such as EDTA, dipicolinic acid or 1,10-phenanthroline. {ECO:0000269|PubMed:14507260}. |
| Subcellular location: | |
Cytoplasm {ECO:0000305}. |
| Similarity: | |
Belongs to the N-acetylmuramoyl-L-alanine amidase 2 family. {ECO:0000305}. |
Annotations taken from UniProtKB at the EBI.