UniProt functional annotation for P37958



	UniProt functional annotation for P37958

UniProt code: P37958.

Organism: Bacillus subtilis (strain 168).

Taxonomy: Bacteria; Firmicutes; Bacilli; Bacillales; Bacillaceae; Bacillus.

Function: Enables the recognition and targeting of unfolded and aggregated proteins to the ClpC protease or to other proteins involved in proteolysis. Acts negatively in the development of competence by binding ComK and recruiting it to the ClpCP protease. When overexpressed, inhibits sporulation. Also involved in Spx degradation by ClpC. {ECO:0000269|PubMed:12598648}.

Subunit: Homodimer. {ECO:0000269|PubMed:10447896}.

Developmental stage: Expressed throughout growth. There is a slight decline of expression during exponential growth and a slight increase after T0.

Domain: The N-terminal domain has binding sites for ComK and ComS and probably for unfolded/aggregated proteins; the C-terminal domain interacts with ClpC. {ECO:0000269|PubMed:10447896}.

Similarity: Belongs to the MecA family. {ECO:0000305}.

Annotations taken from UniProtKB at the EBI.


Organism:		Bacillus subtilis (strain 168).
Taxonomy:		Bacteria; Firmicutes; Bacilli; Bacillales; Bacillaceae; Bacillus.



Function:		Enables the recognition and targeting of unfolded and aggregated proteins to the ClpC protease or to other proteins involved in proteolysis. Acts negatively in the development of competence by binding ComK and recruiting it to the ClpCP protease. When overexpressed, inhibits sporulation. Also involved in Spx degradation by ClpC. {ECO:0000269\|PubMed:12598648}.


Subunit:		Homodimer. {ECO:0000269\|PubMed:10447896}.
Developmental stage:		Expressed throughout growth. There is a slight decline of expression during exponential growth and a slight increase after T0.
Domain:		The N-terminal domain has binding sites for ComK and ComS and probably for unfolded/aggregated proteins; the C-terminal domain interacts with ClpC. {ECO:0000269\|PubMed:10447896}.
Similarity:		Belongs to the MecA family. {ECO:0000305}.