UniProt functional annotation for P08758



	UniProt functional annotation for P08758

UniProt code: P08758.

Organism: Homo sapiens (Human).

Taxonomy: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo.

Function: This protein is an anticoagulant protein that acts as an indirect inhibitor of the thromboplastin-specific complex, which is involved in the blood coagulation cascade.

Subunit: Monomer. Binds ATRX and EIF5B (By similarity). Interacts with hepatitis B virus (HBV). {ECO:0000250, ECO:0000269|PubMed:8249278}.

Domain: The [IL]-x-C-x-x-[DE] motif is a proposed target motif for cysteine S-nitrosylation mediated by the iNOS-S100A8/A9 transnitrosylase complex. {ECO:0000305|PubMed:25417112}.

Domain: A pair of annexin repeats may form one binding site for calcium and phospholipid.

Ptm: S-nitrosylation is induced by interferon-gamma and oxidatively- modified low-densitity lipoprotein (LDL(ox)) possibly implicating the iNOS-S100A8/9 transnitrosylase complex. {ECO:0000305|PubMed:25417112}.

Disease: Pregnancy loss, recurrent, 3 (RPRGL3) [MIM:614391]: A common complication of pregnancy, resulting in spontaneous abortion before the fetus has reached viability. The term includes all miscarriages from the time of conception until 24 weeks of gestation. Recurrent pregnancy loss is defined as 3 or more consecutive spontaneous abortions. {ECO:0000269|PubMed:17339269}. Note=Disease susceptibility is associated with variants affecting the gene represented in this entry.

Similarity: Belongs to the annexin family. {ECO:0000255|PROSITE- ProRule:PRU01245, ECO:0000305}.

Annotations taken from UniProtKB at the EBI.


Organism:		Homo sapiens (Human).
Taxonomy:		Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo.



Function:		This protein is an anticoagulant protein that acts as an indirect inhibitor of the thromboplastin-specific complex, which is involved in the blood coagulation cascade.


Subunit:		Monomer. Binds ATRX and EIF5B (By similarity). Interacts with hepatitis B virus (HBV). {ECO:0000250, ECO:0000269\|PubMed:8249278}.
Domain:		The [IL]-x-C-x-x-[DE] motif is a proposed target motif for cysteine S-nitrosylation mediated by the iNOS-S100A8/A9 transnitrosylase complex. {ECO:0000305\|PubMed:25417112}.
Domain:		A pair of annexin repeats may form one binding site for calcium and phospholipid.
Ptm:		S-nitrosylation is induced by interferon-gamma and oxidatively- modified low-densitity lipoprotein (LDL(ox)) possibly implicating the iNOS-S100A8/9 transnitrosylase complex. {ECO:0000305\|PubMed:25417112}.
Disease:		Pregnancy loss, recurrent, 3 (RPRGL3) [MIM:614391]: A common complication of pregnancy, resulting in spontaneous abortion before the fetus has reached viability. The term includes all miscarriages from the time of conception until 24 weeks of gestation. Recurrent pregnancy loss is defined as 3 or more consecutive spontaneous abortions. {ECO:0000269\|PubMed:17339269}. Note=Disease susceptibility is associated with variants affecting the gene represented in this entry.
Similarity:		Belongs to the annexin family. {ECO:0000255\|PROSITE- ProRule:PRU01245, ECO:0000305}.