UniProt functional annotation for Q9UN36



	UniProt functional annotation for Q9UN36

UniProt code: Q9UN36.

Organism: Homo sapiens (Human).

Taxonomy: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo.

Function: Contributes to the regulation of the Wnt signaling pathway. Down-regulates CTNNB1-mediated transcriptional activation of target genes, such as CCND1, and may thereby act as tumor suppressor. May be involved in dendritic cell and neuron differentiation. {ECO:0000269|PubMed:12845671, ECO:0000269|PubMed:16103061, ECO:0000269|PubMed:21247902}.

Subunit: Interacts with CTNNB1. {ECO:0000269|PubMed:21247902}.

Subcellular location: Cytoplasm. Cytoplasm, perinuclear region. Cell projection, growth cone {ECO:0000250}. Note=In neurons, seems to concentrate at axonal growth cone. Perinuclear in neurons (By similarity). {ECO:0000250}.

Tissue specificity: Highly expressed in brain, heart, skeletal muscle and salivary gland, and moderately in kidney and liver. Expressed in dendritic cells, but not in other blood cells. Expression levels are low in pancreatic and liver cancer tissues; absent in meningioma. Expressed in low-grade gliomas but present at low levels in glioblastoma. Isoform 1 and isoform 2 are present in brain neurons and up-regulated in Alzheimer disease (at protein level). {ECO:0000269|PubMed:11352569, ECO:0000269|PubMed:11936845, ECO:0000269|PubMed:12845671, ECO:0000269|PubMed:14572661, ECO:0000269|PubMed:15207261, ECO:0000269|PubMed:15526377, ECO:0000269|PubMed:16103061}.

Developmental stage: Specifically expressed during dendritic cell differentiation (in vitro). Expression is low in fetal brain and increases during brain postnatal development. {ECO:0000269|PubMed:14572661, ECO:0000269|PubMed:15207261}.

Similarity: Belongs to the NDRG family. {ECO:0000305}.

Sequence caution: Sequence=BAA86562.1; Type=Erroneous initiation; Note=Extended N-terminus.; Evidence={ECO:0000305}; Sequence=CAD62350.1; Type=Erroneous initiation; Note=Extended N-terminus.; Evidence={ECO:0000305};

Annotations taken from UniProtKB at the EBI.


Organism:		Homo sapiens (Human).
Taxonomy:		Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo.



Function:		Contributes to the regulation of the Wnt signaling pathway. Down-regulates CTNNB1-mediated transcriptional activation of target genes, such as CCND1, and may thereby act as tumor suppressor. May be involved in dendritic cell and neuron differentiation. {ECO:0000269\|PubMed:12845671, ECO:0000269\|PubMed:16103061, ECO:0000269\|PubMed:21247902}.


Subunit:		Interacts with CTNNB1. {ECO:0000269\|PubMed:21247902}.
Subcellular location:		Cytoplasm. Cytoplasm, perinuclear region. Cell projection, growth cone {ECO:0000250}. Note=In neurons, seems to concentrate at axonal growth cone. Perinuclear in neurons (By similarity). {ECO:0000250}.
Tissue specificity:		Highly expressed in brain, heart, skeletal muscle and salivary gland, and moderately in kidney and liver. Expressed in dendritic cells, but not in other blood cells. Expression levels are low in pancreatic and liver cancer tissues; absent in meningioma. Expressed in low-grade gliomas but present at low levels in glioblastoma. Isoform 1 and isoform 2 are present in brain neurons and up-regulated in Alzheimer disease (at protein level). {ECO:0000269\|PubMed:11352569, ECO:0000269\|PubMed:11936845, ECO:0000269\|PubMed:12845671, ECO:0000269\|PubMed:14572661, ECO:0000269\|PubMed:15207261, ECO:0000269\|PubMed:15526377, ECO:0000269\|PubMed:16103061}.
Developmental stage:		Specifically expressed during dendritic cell differentiation (in vitro). Expression is low in fetal brain and increases during brain postnatal development. {ECO:0000269\|PubMed:14572661, ECO:0000269\|PubMed:15207261}.
Similarity:		Belongs to the NDRG family. {ECO:0000305}.
Sequence caution:		Sequence=BAA86562.1; Type=Erroneous initiation; Note=Extended N-terminus.; Evidence={ECO:0000305}; Sequence=CAD62350.1; Type=Erroneous initiation; Note=Extended N-terminus.; Evidence={ECO:0000305};