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UniProt functional annotation for P67911 | ||
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| UniProt code: P67911. |
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| Organism: | |
Escherichia coli O157:H7. |
| Taxonomy: | |
Bacteria; Proteobacteria; Gammaproteobacteria; Enterobacterales; Enterobacteriaceae; Escherichia. |
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| Function: | |
Catalyzes the interconversion between ADP-D-glycero-beta-D- manno-heptose and ADP-L-glycero-beta-D-manno-heptose via an epimerization at carbon 6 of the heptose. {ECO:0000255|HAMAP- Rule:MF_01601}. |
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| Catalytic activity: | |
Reaction=ADP-D-glycero-beta-D-manno-heptose = ADP-L-glycero-beta-D- manno-heptose; Xref=Rhea:RHEA:17577, ChEBI:CHEBI:59967, ChEBI:CHEBI:61506; EC=5.1.3.20; Evidence={ECO:0000255|HAMAP- Rule:MF_01601}; |
| Cofactor: | |
Name=NADP(+); Xref=ChEBI:CHEBI:58349; Evidence={ECO:0000255|HAMAP-Rule:MF_01601}; Note=Binds 1 NADP(+) per subunit. {ECO:0000255|HAMAP-Rule:MF_01601}; |
| Pathway: | |
Nucleotide-sugar biosynthesis; ADP-L-glycero-beta-D-manno- heptose biosynthesis; ADP-L-glycero-beta-D-manno-heptose from D- glycero-beta-D-manno-heptose 7-phosphate: step 4/4. {ECO:0000255|HAMAP- Rule:MF_01601}. |
| Pathway: | |
Bacterial outer membrane biogenesis; LPS core biosynthesis. |
| Subunit: | |
Homopentamer. {ECO:0000255|HAMAP-Rule:MF_01601}. |
| Induction: | |
By heat shock. {ECO:0000250}. |
| Domain: | |
Contains a large N-terminal NADP-binding domain, and a smaller C-terminal substrate-binding domain. {ECO:0000255|HAMAP-Rule:MF_01601}. |
| Similarity: | |
Belongs to the NAD(P)-dependent epimerase/dehydratase family. HldD subfamily. {ECO:0000255|HAMAP-Rule:MF_01601}. |
Annotations taken from UniProtKB at the EBI.