PDBsum entry 2x1v

Hydrolase

PDB id: 2x1v

Contents

Protein chain

139 a.a. *

Ligands

GDP

Waters ×116

* Residue conservation analysis

PDB id:

2x1v

Name:

Hydrolase

Title:

Crystal structure of the activating h-ras i163f mutant in costello syndrome, bound to mg-gdp

Structure:

Gtpase hras. Chain: a. Fragment: g-domain, residues 1-166. Synonym: transforming protein p21, p21ras, h-ras-1, c-h-ras, ha-ras. Engineered: yes. Mutation: yes

Source:

Homo sapiens. Human. Organism_taxid: 9606. Expressed in: escherichia coli. Expression_system_taxid: 562

Resolution:

1.70Å R-factor: 0.191 R-free: 0.227

Authors:

K.Anand

Key ref:

K.Anand et al. Crystal structure of the activating h-Rask117r mutant in costello syndrome, Bound to mg-Gdp. To be published, .

Date:

04-Jan-10 Release date: 12-Jan-10

Protein chain

P01112  (RASH_HUMAN) -  GTPase HRas from Homo sapiens

Seq: 189 a.a.

Struc: 139 a.a.*

* PDB and UniProt seqs differ at 1 residue position (black cross)

Enzyme reactions

• Enzyme class: E.C.3.6.5.2 - small monomeric GTPase.
• Reaction: GTP + H2O = GDP + phosphate + H⁺

GTP + H2O = GDP (Bound ligand (Het Group name = GDP) corresponds exactly) + phosphate + H(+)

Molecule diagrams generated from .mol files obtained from the KEGG ftp site