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UniProt functional annotation for P69054 | ||
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| UniProt code: P69054. |
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| Organism: | |
Escherichia coli (strain K12). |
| Taxonomy: | |
Bacteria; Proteobacteria; Gammaproteobacteria; Enterobacterales; Enterobacteriaceae; Escherichia. |
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| Function: | |
Membrane-anchoring subunit of succinate dehydrogenase (SDH). |
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| Cofactor: | |
Name=heme; Xref=ChEBI:CHEBI:30413; Note=The heme is bound between the two transmembrane subunits.; |
| Pathway: | |
Carbohydrate metabolism; tricarboxylic acid cycle. |
| Subunit: | |
Part of an enzyme complex containing four subunits: a flavoprotein, an iron-sulfur protein, plus two membrane-anchoring proteins, SdhC and SdhD. The complex can form homotrimers. {ECO:0000269|PubMed:12560550, ECO:0000269|PubMed:16407191, ECO:0000269|PubMed:19710024}. |
| Subcellular location: | |
Cell inner membrane; Multi-pass membrane protein. |
| Miscellaneous: | |
His-84 provides an axial ligand to heme b556 in the wild-type enzyme. The retention of low spin heme b556 in the SdhC 'Leu- 84' mutant suggests that swapping of the heme axial ligand by His-91 or His-30 is possible. |
| Similarity: | |
Belongs to the cytochrome b560 family. {ECO:0000305}. |
Annotations taken from UniProtKB at the EBI.