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UniProt functional annotation for Q389T8 | ||
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| UniProt code: Q389T8. |
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| Organism: | |
Trypanosoma brucei brucei (strain 927/4 GUTat10.1). |
| Taxonomy: | |
Eukaryota; Discoba; Euglenozoa; Kinetoplastea; Metakinetoplastina; Trypanosomatida; Trypanosomatidae; Trypanosoma. |
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| Function: | |
Trypanothione is the parasite analog of glutathione; this enzyme is the equivalent of glutathione reductase. {ECO:0000256|ARBA:ARBA00003667}. |
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| Catalytic activity: | |
Reaction=NADP(+) + trypanothione = H(+) + NADPH + trypanothione disulfide; Xref=Rhea:RHEA:16757, ChEBI:CHEBI:15378, ChEBI:CHEBI:57783, ChEBI:CHEBI:58290, ChEBI:CHEBI:58349, ChEBI:CHEBI:58661; EC=1.8.1.12; Evidence={ECO:0000256|ARBA:ARBA00001054}; |
| Cofactor: | |
Name=FAD; Xref=ChEBI:CHEBI:57692; Evidence={ECO:0000256|ARBA:ARBA00001974}; |
| Cofactor: | |
Name=FAD; Xref=ChEBI:CHEBI:57692; Evidence={ECO:0000256|PIRSR:PIRSR000350-3}; Note=Binds 1 FAD per subunit. {ECO:0000256|PIRSR:PIRSR000350-3}; |
| Subunit: | |
Homodimer. {ECO:0000256|ARBA:ARBA00011738}. |
| Similarity: | |
Belongs to the class-I pyridine nucleotide-disulfide oxidoreductase family. {ECO:0000256|ARBA:ARBA00007532, ECO:0000256|RuleBase:RU003691}. |
Annotations taken from UniProtKB at the EBI.