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UniProt functional annotation for P03195 | ||
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| UniProt code: P03195. |
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| Organism: | |
Epstein-Barr virus (strain B95-8) (HHV-4) (Human herpesvirus 4). |
| Taxonomy: | |
Viruses; Duplodnaviria; Heunggongvirae; Peploviricota; Herviviricetes; Herpesvirales; Herpesviridae; Gammaherpesvirinae; Lymphocryptovirus. |
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| Function: | |
Involved in nucleotide metabolism: produces dUMP, the immediate precursor of thymidine nucleotides and decreases the intracellular concentration of dUTP to avoid uracil incorporation into viral DNA. {ECO:0000255|HAMAP-Rule:MF_04031}. |
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| Catalytic activity: | |
Reaction=dUTP + H2O = diphosphate + dUMP + H(+); Xref=Rhea:RHEA:10248, ChEBI:CHEBI:15377, ChEBI:CHEBI:15378, ChEBI:CHEBI:33019, ChEBI:CHEBI:61555, ChEBI:CHEBI:246422; EC=3.6.1.23; Evidence={ECO:0000255|HAMAP-Rule:MF_04031}; |
| Cofactor: | |
Name=Mg(2+); Xref=ChEBI:CHEBI:18420; Evidence={ECO:0000255|HAMAP-Rule:MF_04031}; |
| Subunit: | |
Monomer. {ECO:0000269|PubMed:16154087}. |
| Similarity: | |
Belongs to the dUTPase family. {ECO:0000255|HAMAP- Rule:MF_04031}. |
Annotations taken from UniProtKB at the EBI.