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PDBsum entry 2wc3
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References listed in PDB file
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Key reference
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Title
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Glycosidase inhibition by ring-Modified castanospermine analogues: tackling enzyme selectivity by inhibitor tailoring.
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Authors
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M.Aguilar-Moncayo,
T.M.Gloster,
J.P.Turkenburg,
M.I.García-Moreno,
C.Ortiz mellet,
G.J.Davies,
J.M.García fernández.
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Ref.
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Org Biomol Chem, 2009,
7,
2738-2747.
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PubMed id
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Abstract
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Synthesis of a panel of iso(thio)urea-type ring-modified castanospermine
analogues bearing a freely mutarotating pseudoanomeric hydroxyl group results in
tight-binding beta-glucosidase inhibitors with unusual binding signatures; the
presence of an N-octyl substituent imparts a remarkable anomeric selectivity,
promoting strong binding of the appropriate beta-anomer by the beta-glucosidase.
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