UniProt functional annotation for Q6JAM6



	UniProt functional annotation for Q6JAM6

UniProt code: Q6JAM6.

Organism: Lagos bat virus (LBV).

Taxonomy: Viruses; Riboviria; Orthornavirae; Negarnaviricota; Haploviricotina; Monjiviricetes; Mononegavirales; Rhabdoviridae; Lyssavirus.

Function: Plays a major role in assembly and budding of virion. Completely covers the ribonucleoprotein coil and keep it in condensed bullet-shaped form. Inhibits viral transcription and stimulates replication. Plays a major role in early induction of TRAIL-mediated apoptosis in infected neurons (By similarity). {ECO:0000250}.

Subunit: Homomultimer. Interacts with nucleoprotein and with the cytoplasmic domain of glycoprotein (By similarity). {ECO:0000250}.

Subcellular location: Virion membrane; Peripheral membrane protein. Host endomembrane system {ECO:0000250}; Peripheral membrane protein {ECO:0000250}.

Domain: Late-budding domains (L domains) are short sequence motifs essential for viral particle budding. They recruit proteins of the host ESCRT machinery (Endosomal Sorting Complex Required for Transport) or ESCRT-associated proteins. Matrix protein contains one L domain: a PPXY motif which potentially interacts with the WW domain 3 of NEDD4 E3 ubiquitin ligase (Potential). {ECO:0000305}.

Miscellaneous: Most abundant protein in the virion. {ECO:0000250}.

Similarity: Belongs to the lyssavirus matrix protein family. {ECO:0000305}.

Annotations taken from UniProtKB at the EBI.


Organism:		Lagos bat virus (LBV).
Taxonomy:		Viruses; Riboviria; Orthornavirae; Negarnaviricota; Haploviricotina; Monjiviricetes; Mononegavirales; Rhabdoviridae; Lyssavirus.



Function:		Plays a major role in assembly and budding of virion. Completely covers the ribonucleoprotein coil and keep it in condensed bullet-shaped form. Inhibits viral transcription and stimulates replication. Plays a major role in early induction of TRAIL-mediated apoptosis in infected neurons (By similarity). {ECO:0000250}.


Subunit:		Homomultimer. Interacts with nucleoprotein and with the cytoplasmic domain of glycoprotein (By similarity). {ECO:0000250}.
Subcellular location:		Virion membrane; Peripheral membrane protein. Host endomembrane system {ECO:0000250}; Peripheral membrane protein {ECO:0000250}.
Domain:		Late-budding domains (L domains) are short sequence motifs essential for viral particle budding. They recruit proteins of the host ESCRT machinery (Endosomal Sorting Complex Required for Transport) or ESCRT-associated proteins. Matrix protein contains one L domain: a PPXY motif which potentially interacts with the WW domain 3 of NEDD4 E3 ubiquitin ligase (Potential). {ECO:0000305}.
Miscellaneous:		Most abundant protein in the virion. {ECO:0000250}.
Similarity:		Belongs to the lyssavirus matrix protein family. {ECO:0000305}.