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PDBsum entry 2w2j
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References listed in PDB file
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Key reference
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Title
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Crystal structure of human carbonic anhydrase-Related protein VIII reveals the basis for catalytic silencing.
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Authors
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S.S.Picaud,
J.R.Muniz,
A.Kramm,
E.S.Pilka,
G.Kochan,
U.Oppermann,
W.W.Yue.
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Ref.
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Proteins, 2009,
76,
507-511.
[DOI no: ]
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PubMed id
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Note: In the PDB file this reference is
annotated as "TO BE PUBLISHED". The citation details given above have
been manually determined.
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Abstract
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No abstract given.
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Figure 1.
Figure 1. Crystal structure of hCA VIII. (A) Ribbon diagram
showing the secondary structure elements:  -helices
(red) and  -strands
(yellow). (B) C^  -superposition
of hCA VIII (blue) and hCA XIII structures (cyan, PDB code
3DA2). The two loop regions that are unique in hCA VIII are
shown in thick ribbons.
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Figure 2.
Figure 2. Structural comparison of hCA VIII with the catalytic
isozymes. (A) A close-up view showing the entrance of the hCA
VIII cavity. hCA VIII is represented in blue ribbon, overlayed
with a surface representation. (B) Active site of the
CO[2]-bound hCA II (left, PDB code 3D92) and hCA VIII (right)
structures. The hydrophobic CO[2] pocket is shown in pink
surface. Spheres represent the Zn^2+ ion (black), water (red)
and Cl^- ion (green). In the right panel, the CO[2] substrate
from the hCA II structure (shown in dots) is superimposed onto
the hCA VIII structure to illustrate the potential steric clash
caused by I165 and I143 (green surface). (C) Schematic
representation of the Zn^2+ coordination in hCA II (left), and
Cl^- coordination in hCA VIII (right). Bond lengths are
indicated in Å.
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The above figures are
reprinted
by permission from John Wiley & Sons, Inc.:
Proteins
(2009,
76,
507-511)
copyright 2009.
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