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UniProt functional annotation for Q9ESV6 | ||
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| UniProt code: Q9ESV6. |
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| Organism: | |
Rattus norvegicus (Rat). |
| Taxonomy: | |
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus. |
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| Function: | |
May play an important role in regulating the switch between different pathways for energy production during spermiogenesis and in the spermatozoon. Required for sperm motility and male fertility (By similarity). {ECO:0000250}. |
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| Catalytic activity: | |
Reaction=D-glyceraldehyde 3-phosphate + NAD(+) + phosphate = (2R)-3- phospho-glyceroyl phosphate + H(+) + NADH; Xref=Rhea:RHEA:10300, ChEBI:CHEBI:15378, ChEBI:CHEBI:43474, ChEBI:CHEBI:57540, ChEBI:CHEBI:57604, ChEBI:CHEBI:57945, ChEBI:CHEBI:59776; EC=1.2.1.12; Evidence={ECO:0000255|PROSITE-ProRule:PRU10009}; |
| Pathway: | |
Carbohydrate degradation; glycolysis; pyruvate from D- glyceraldehyde 3-phosphate: step 1/5. |
| Subunit: | |
Homotetramer. {ECO:0000250}. |
| Subcellular location: | |
Cytoplasm {ECO:0000250}. |
| Tissue specificity: | |
Expressed in both head and flagellum of epididymal sperm. {ECO:0000269|PubMed:19423663}. |
| Domain: | |
The testis-specific N-terminal extension mediates tight association with the cytoskeletal fibrous sheath of the spermatozoa flagellum, possibly via interchain disulfide-bonding of Cys-33 with sheath components. {ECO:0000250}. |
| Similarity: | |
Belongs to the glyceraldehyde-3-phosphate dehydrogenase family. {ECO:0000305}. |
Annotations taken from UniProtKB at the EBI.