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PDBsum entry 2vvt
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References listed in PDB file
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Key reference
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Title
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Exploring 9-Benzyl purines as inhibitors of glutamate racemase (muri) in gram-Positive bacteria.
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Authors
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B.Geng,
G.Breault,
J.Comita-Prevoir,
R.Petrichko,
C.Eyermann,
T.Lundqvist,
P.Doig,
E.Gorseth,
B.Noonan.
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Ref.
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Bioorg Med Chem Lett, 2008,
18,
4368-4372.
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PubMed id
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Abstract
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An early SAR study of a screening hit series has generated a series of 9-benzyl
purines as inhibitors of bacterial glutamate racemase (MurI) with micromolar
enzyme potency and improved physical properties. X-ray co-crystal EI structures
were obtained.
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